Abstract
Perhaps there is no area of alcohol related research so diverse in the methods used than the area of preference testing. The number and variety of paradigms for testing an animal’s preference or rejection of alcohol solutions seeming is limited only by the number of investigators in the field. This has led to an amazing variety of paradigms and interpretations. While there are now a number of accepted findings, the path to these findings would have been greatly accelerated if a standardized testing paradigm had been employed by investigators in order to make comparisons between laboratories easier. Many studies are internally consistent but the effects observed may be peculiar to the paradigm used and not generally applicable.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, S.M., and McClearn, G.E., 1981. Ethanol consumption: Selective breeding in mice. Behavior Genetics 11, 291 – 301.
Beardsley, P.M., and Meisch, R A., 1981. A precision drinking device for rats tested with water, etionitazene, and ethanol. Pharm. Biochem. Behav. 14, 871 – 876.
Conger, J J., Sawrey, W.L., and Turrell, E.S., 1958. The role of social experience in the production of gastric ulcers in hooded rats placed in a conflict situation. J. Soc. Psych. 57, 214 – 220.
D’Amour, F., and Smith, D.L., 1941. A method for testing loss of pain sensation. J. Pharmacol. Exptl. Therap. 72, 74 – 79.
Deutsch, J.A., Eisner, A., 1977. Ethanol self-administration in the rat induced by forced drinking of ethanol. Behav. Biol. 20, 81 – 90.
Ellison, G.D., 1981. A novel animal model of alcohol consumption based on the development of extremes of ethanol preference in colony-housed but not isolated rats. Behav. Neurol. Biol. 31, 324 – 330.
Eriksson, K., and Russi, M., 1981. Finnish selection studies on alcohol related behaviors: General outline, in McClearn, G.E., Deitrich, R.A. and Erwin, V.G., eds., Development of Animal Models as Pharmacogenetic Tools. Res. Monograph No. 6, National Institute on Alcohol Abuse and Alcoholism, Washington, D.C. pp. 87 – 117.
Fadda, F., Mosca, E., Colombo, G., and Gessa, G.L., 1990. Alcohol-preferring rats: Genetic sensitivity to alcohol–induced stimulation of dopamine metabolism. Physiol. Behav. 47, 727 – 729.
Froehlich, J.C., Harts, J., Lumeng, L., and Li, T.-K., 1990. Naloxone attenuates voluntary ethanol intake in rats selectively bred for high ethanol preference. Pharm. Biochem. Behav. 35, 385 – 390.
Gilbert, R.M., 1978. Schedule induction and sweetness as factors in ethanol consumption and preference by rats. Pharm. Biochem. Behav. 8, 739 – 741.
Gill, K., Amit, Z., and Ogren, S.O., 1984. Selective depletion of norepinephrine in brain by N-2-chloroethyl-n-ethyl-2-bromobenzylamine fails to alter the voluntary consumption of ethanol in rats. Neuropharmacology 23, 1379 – 1383.
Gill, K., Mundl, W J., Cabilio, S., and Amit, Z., 1989. A microprocessor controlled data acquisition system for research on feeding and drinking behavior in rats. Physiol. Behav. 45, 741 – 746.
Gill, T J., Ill, Smith, G J., Wissler, R.W., and Kunz, H.W., 1989. The rat as an experimental animal. Science 245, 269 – 275.
Lawrin, M.O., Naranjo, CA., and Sellers, E.M., 1986. Identification of new drugs for modulating ethanol consumption. Psychopharm. Bull 22, 1020 – 1025.
Li, T.-K., and Lumeng, L., 1984. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Alc.: Clin. Exp. Res. 8, 485 – 486.
Li, T.-K., Lumeng, L., McBride, WJ., and Waller, M.B., 1981. Indiana selection studies on alcohol related behaviors, in McClearn, G.E.Deitrich, R.A. and Erwin, V.G., eds., Development of Animal Models as Pharmacogenetic Tools. Res. Monograph No. 6, National Institute on Alcohol Abuse and Alcoholism, Washington, D.C. pp. 171–191
Linseman, MA., 1987. Alcohol consumption is free–feeding rats: Procedural, genetic and pharmacokinetic factors. Psychopharmacology 92, 254 – 261.
Mardones, J., and Segovia-Riquelme, N., 1983. Thrity-two years of selection of rats by ethanol preference: UChA and UChB strains. Neurobehav. Toxicol. Teratol. 5, 171 – 178.
Pickett, R.A., III, and Collins, A.C., 1975. Use of genetic analysis to test the potential role of serotonin in alcohol preference. Life Sci. 17,1291– 1296.
Privette, T.H., Hornsby, R.L., and Myers, R.D., 1988. Buspirone alters alcohol drinking induced in rats by tetrahydropapaveroline injected into brain monoaminergic pathways. Alcohol 5, 147 – 152.
Samson, H.H., Tolliver, G A., Lumeng, L., and Li, T.KL, 1989. Ethanoi reinforcement in the alcohol nonpreferring rat: Initiation using behavioral techniques without food restriction. Alc.: Clin. Exp. Res. 13, 378 – 384.
Waller, M.B., McBride, WJ., Gatto, GJ., Lumeng, L., and Li, T.-K., 1984. Intragastric self-infusion of ethanoi by ethanol–preferring and non-preferring lines of rats. Science 225, 78 – 80.
York, J.L., 1981. Consumption of intoxicating beverages by rats and mice exhibiting high and low preferences for ethanoi. Pharm. Biochem. Behav. 15, 207 – 214.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag New York, Inc.
About this paper
Cite this paper
Deitrich, R.A. (1992). Animal Models for Testing Drug Effects on Alcohol Consumption. In: Naranjo, C.A., Sellers, E.M. (eds) Novel Pharmacological Interventions for Alcoholism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2878-3_1
Download citation
DOI: https://doi.org/10.1007/978-1-4612-2878-3_1
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-7705-7
Online ISBN: 978-1-4612-2878-3
eBook Packages: Springer Book Archive