Skip to main content

Immunological Contraception

  • Chapter
Contraception

Part of the book series: Clinical Perspectives in Obstetrics and Gynecology ((CPOG))

  • 141 Accesses

Abstract

As presented in other chapters of this book, there is a plethora of contraceptive methods currently in use to prevent an unwanted pregnancy. Many of these methods are safe and highly effective for blocking fertility while others are less effective or have health risks associated with their use. All current contraceptive methods have some shortcomings related either to efficacy, safety, cost, ease of use, or conflict with moral or religious values. In many circumstances, poor families or those living in developing countries have no means to access methods for planning family size or if methods are available, they are not affordable. Thus, it is apparent to those knowledgeable of family planning needs that additional contraceptive technology is essential to meet current and future demands.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Stevens VC, Powell JE, Rickey M, et al. Studies of various delivery systems for a human chorionic gonadotropin vaccine. In Alexander NJ, Griffin PD, Spieler JM, Waites GMH (eds): Gamete Interaction. New York, Wiley-Liss, 1990; 549–563.

    Google Scholar 

  2. Ladd A, Tsong YY, Prabhu G, et al. Effects of long-term immunization against LHRH and androgen treatment on gonadal function. J Reprod Immunol 1989; 15: 85–101.

    Article  PubMed  CAS  Google Scholar 

  3. Joel CA. Historical survey of research on spermatozoa from antiquity to the present. In Joel CA (ed): Fertility Disturbances in Men and Women. Basel, Krager, 1971; 3–20.

    Google Scholar 

  4. Goldberg E, Shelton JA. Immunosuppression of fertility by LDH-C4. In Talwar GP (ed): Immunological Approaches to Contraception and Promotion of Fertility. New York, Plenum Press, 1986; 219–230.

    Google Scholar 

  5. Mahi-Brown CA, Vandevoort CA, Ryan P, et al. Immunization of male but not female mice with the sperm-specific isozyme of lactate de-hydrogenase (LDH-C4) impairs fertilization in vivo. Am J Reprod Immunol 1990; 24: 1–8.

    PubMed  CAS  Google Scholar 

  6. Goldberg E. LDH-C4 as an immunocontraceptive model. In Alexander NJ, Griffin PD, Spieler JM, Waites GMH (eds): Gamete Interaction. New York, Wiley-Liss, 1990; 63–74.

    Google Scholar 

  7. Herr JC, Flickinger CJ, Humyk M, et al. Biochemical and morphological characterization of the intra-acrosomal antigen SP-10 from human sperm. Biol Reprod 1990; 42: 181–193.

    Article  PubMed  CAS  Google Scholar 

  8. Primakoff P, Lathrop W, Woolman L. Fully effective contraception in male and female guinea pigs immunized with the sperm protein PH-20. Nature 1988; 335: 543–546.

    Article  PubMed  CAS  Google Scholar 

  9. Sacco Ag, Yarewicz EC, Subramanian MG. Effect of varying dosages and adjuvants on antibody response in squirrel monkeys immunized with porcine zona pellucida glycoprotein ZP-3. Am J Reprod Immunol 1989; 21: 1–8.

    Google Scholar 

  10. Millar SE, Chamow SM, Balir AW, et al. Vaccination with a synthetic zona pellucida peptide produces long-term contraception in female mice. Science 1989; 246: 935–938.

    Article  PubMed  CAS  Google Scholar 

  11. Stevens VC. Immunization of female baboons with haptencoupled gonadotropins. Obstet Gynecol 1973; 42: 496–506.

    Article  PubMed  CAS  Google Scholar 

  12. Talwar GP, Sharma NC, Dubey SK, et al. Isoimmunization against human chorionic gonadotropin with conjugates of processed B- subunit of the hormone and tetanus toxoid. Proc Natl Acad Sei 1976; 73: 218–222.

    Article  CAS  Google Scholar 

  13. Stevens VC, Cinader B, Powell JE, et al. Preparation and formulation of a hCG antifertility vaccine: selection of peptide immunogen. Am J Reprod Immunol 1981a; 6: 307–314.

    Google Scholar 

  14. Stevens VC, Cinader B, Powell JE, et al. Preparation and formulation of a hCG antifertility vaccine: selection of adjuvant and vehicle. Am J Reprod Immunol 1981b; 6: 315–321.

    Google Scholar 

  15. Lee AC, Powell JE, Tregear G, et al. A method for preparing B-hCG COOH peptide-carrier conjugates of predictable composition. Mol Immunol 1980; 17: 749–755.

    Article  PubMed  CAS  Google Scholar 

  16. Thau RB, Sundaram K. The mechanism of action of an antifertility vaccine in the rhesus monkey: reversal of the effects of antisera to the B-subunit of ovine luteinizing hormone by medroxy progesterone acetate. Fertil Steril 1980; 33: 317–321.

    PubMed  CAS  Google Scholar 

  17. Nash H, Talwar GP, Segal S, et al. Observations on the antigenicity and clinical effects of a candidate antipregnancy vaccine: B-subunit of human chorionic gonadotropin linked to tetanus toxoid. Fertil Steril 1980; 34: 328–334.

    PubMed  CAS  Google Scholar 

  18. Talwar GP, Guar A. Recent developments in immunocontraception. Am J Obstet Gynecol 1987; 157: 1075–1079.

    PubMed  CAS  Google Scholar 

  19. Jones WR, Bradley J, Judd ST, et al. Phase I clinical trial of a World Health Organization birth control vaccine. Lancet 1988; 1: 1295–1298.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag New York, Inc.

About this chapter

Cite this chapter

Stevens, V.C. (1993). Immunological Contraception. In: Shoupe, D., Haseltine, F.P. (eds) Contraception. Clinical Perspectives in Obstetrics and Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2730-4_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-2730-4_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7645-6

  • Online ISBN: 978-1-4612-2730-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics