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Molecular and Cellular Aspects of Periimplantation Processes pp 67–83Cite as

Differential Gene Expressions and Programmed Cell Death in the Two Cell Populations Forming the Rat Decidua

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Pregnancy requires profound changes and severe reorganization of the different tissues forming the uterus. The most striking event that takes place in the uterine milieu is the rapid growth and differentiation of the endometrial stroma giving rise to unique cells, termed decidual cells, that differ totally from the original fibroblast cells. For reasons not yet understood, decidualization gives rise to two different cell populations located on opposite sides of the uterine lumen. Blastocyst implantation and the initiation of decidualization always occur in the antimesometrial site of the uterus, where the stromal endometrial cells undergo rapid growth and differentiation. Only two days later, decidualization takes place in the mesometrial region. The cells that decidualize in the antimesometrial site become extensively differentiated; they are large, polyploid, and tightly packed. In contrast, the mesometrial stromal cells undergo only limited differentiation; they are small, rarely polyploid, and loosely connected.

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Authors
  1. Geula Gibori
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  2. Yan Gu
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  3. R. K. Srivastava
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Kansas Medical Center, Kansas City, KS, 66160, USA

    S. K. Dey Ph.D.

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© 1995 Springer-Verlag New York, Inc.

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Gibori, G., Gu, Y., Srivastava, R.K. (1995). Differential Gene Expressions and Programmed Cell Death in the Two Cell Populations Forming the Rat Decidua. In: Dey, S.K. (eds) Molecular and Cellular Aspects of Periimplantation Processes. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2548-5_5

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  • DOI: https://doi.org/10.1007/978-1-4612-2548-5_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7575-6

  • Online ISBN: 978-1-4612-2548-5

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