Abstract
In Chapter 7, the topic of biodynamics was introduced in reference to changes in the rate of messenger RNA production using a single-compartment model. If the point of gene expression is to convert the latent information in DNA into the protein catalysts that conduct most of the business of the cell, then it is necessary to link any change in messenger RNA production to a change in protein synthesis. This chapter demonstrates a model of gene expression that includes production of mRNA and synthesis of protein. Chapter 17 extends these ideas to the level of the phenotype and develops a more comprehensive model of gene expression.
Decay of RNA must have evolved in response to the evolution of the RNA synthetic capacity, otherwise the world would have been clogged with macromolecules and no new cells or any other biological entities could have developed.
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Hargrove, J.L. (1998). Kinetic Genetics: Compartmental Models of Gene Expression. In: Dynamic Modeling in the Health Sciences. Modeling Dynamic Systems. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1644-5_16
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DOI: https://doi.org/10.1007/978-1-4612-1644-5_16
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