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Genetic Problems and Congenital Malformations in 1987 ICSI Children

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Male Sterility and Motility Disorders

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

When assisted fertilization and intracytoplasmic sperm injection (ICSI) were introduced, there was major concern about the safety of the newly introduced technique. Intracytoplasmic sperm injection is indeed a more invasive procedure than routine IVF because one spermatozoon is injected through the oo-cyte membrane and because fertilization can be obtained from sperm that could never have been used before in fertility treatment. Even more questions arose and concern was again expressed when ICSI with nonejaculated spermatozoa, either epidididymal or testicular, was introduced. Emphasis was put on the fact that because more chromosomal aberrations are found in azoospermic males and more in particular in case of nonobstructive azoosper-mia, the risk for chromosomal aberrations in the offspring might even be higher. Other heritable genetic causes might also be involved. On the other hand, it was suspected that imprinting may be less complete at the time of fertilization if testicular sperm is used. If this were so, then it would be unlikely to impair fertilization and early development, but anomalies might become manifest at birth or only later in life.

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Authors
  1. Maryse Bonduelle
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  2. Ayse Aytoz
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  3. Ann Wilikens
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  4. Andrea Buysse
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  5. Elvire Van Assche
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  6. Paul Devroey
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  7. Andre Van Steirteghem
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  8. Inge Liebaers
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Editor information

Editors and Affiliations

  1. Service de FIV, Hôpital A. Béclère, 92141, Clamart cedex, France

    Samir Hamamah Ph.D.

  2. Service de Gynéco-Obstétrique, Hôpital A. Béclère, 157, rue de la Porte-de-Trivaux, 92141, Clamart cedex, France

    François Olivennes M.D., Ph.D.  & René Frydman Ph.D.  & 

  3. Centre de Stérilité Masculine, Hôpital de la Grave, 31052, Toulouse cedex, France

    Roger Mieusset M.D.

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© 1999 Springer Science+Business Media New York

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Bonduelle, M. et al. (1999). Genetic Problems and Congenital Malformations in 1987 ICSI Children. In: Hamamah, S., Olivennes, F., Mieusset, R., Frydman, R. (eds) Male Sterility and Motility Disorders. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1522-6_26

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  • DOI: https://doi.org/10.1007/978-1-4612-1522-6_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7177-2

  • Online ISBN: 978-1-4612-1522-6

  • eBook Packages: Springer Book Archive

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