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Interleukin-11: Potential Therapeutic Activity in Systemic Inflammatory States

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Multiple Organ Failure

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Abstract

Interleukin-11 IL-11) is a multifunctional, immunoregulatory cytokine with several unique attributes that has therapeutic potential in a number of systemic inflammatory states. Like many other pleiotropic cytokines, IL-11 has myriad biologic activities that could be beneficial in the treatment of selected patient populations. IL-11 functions as a growth factor, cytoprotective molecule, antiinflammatory cytokine, regulator of enzymatic activity, and cell maturation factor depending on the target tissue.1,2 It has also received regulatory approval as a platelet restorative agent following cytoreductive chemotherapy3. The numerous physiologic activities of IL-11 offer an opportunity to explore many other potential therapeutic indications for this cytokine in clinical medicine. Systemic inflammatory syndromes such as septic shock, inflammatory bowel disease, inflammatory arthritis, preeclampsia, ischemia/reperfusion injury, chemotherapy- and radiation-induced mucositis, and a variety of other hematologic and immunologic disorders may be amenable to IL-11 therapy.1,3,4 This chapter focuses on those attributes of IL-11 that make it an attractive candidate for treatment of systemic inflammatory disorders including septic shock.

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Authors
  1. Steven M. Opal
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  2. James C. Keith Jr.
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Editor information

Editors and Affiliations

  1. Department of Surgery, St. Louis University Hospital, St. Louis, Missouri, 63110, USA

    Arthur E. Baue MD (Professor Emeritus) (Professor Emeritus)

  2. Department of Surgery, Klinikum Grosshadern, University of Munich, Munich, D-81377, Germany

    Eugen Faist MD (Professor) (Professor)

  3. Department of Surgery, School of Medicine, University of New Mexico, Albuquerque, New Mexico, 87131, USA

    Donald E. Fry MD (Professor and Chairman) (Professor and Chairman)

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Opal, S.M., Keith, J.C. (2000). Interleukin-11: Potential Therapeutic Activity in Systemic Inflammatory States. In: Baue, A.E., Faist, E., Fry, D.E. (eds) Multiple Organ Failure. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1222-5_54

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  • DOI: https://doi.org/10.1007/978-1-4612-1222-5_54

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7049-2

  • Online ISBN: 978-1-4612-1222-5

  • eBook Packages: Springer Book Archive

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