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The Role of Free Radicals in Cancer and Aging

  • Chapter
Trace Elements, Micronutrients, and Free Radicals

Part of the book series: Contemporary Issues in Biomedicine, Ethics, and Society ((CIBES))

Abstract

There is increasing evidence that the progress of biologic aging results from accumulated free radical damage, and that a significant fraction of cancer is also caused by deleterious free radical reactions. Free radicals originate from the utilization of oxygen and the metabolism of organic compounds, and can be scavenged in living organisms by a range of enzymes and small antioxidant molecules. In this review, the various theories of aging are examined, as are the possible origins of cancer. The mitochondrion is proposed as the common link between cancer and aging, and the free radical reactions that occur in the mitochondrion are explained. Some of the important free radical reactions, both essential and deleterious, that occur continuously in a living organism, are discussed, and an outline is given of the multi-layered defense system that all aerobic organisms have against excess free radicals. The possibility that rate of aging and cancer incidence can be reduced by dietary supplementation with antioxidants is discussed in light of human and animal experiments, and suggestions are given for future research into the role of free radicals in health and disease.

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  1. T. Mark Florence
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  1. Division of Human Nutrition, CSIRO, Adelaide, Australia

    Ivor E. Dreosti

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Florence, T.M. (1991). The Role of Free Radicals in Cancer and Aging. In: Dreosti, I.E. (eds) Trace Elements, Micronutrients, and Free Radicals. Contemporary Issues in Biomedicine, Ethics, and Society. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0419-0_8

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  • DOI: https://doi.org/10.1007/978-1-4612-0419-0_8

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