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Negative Pressure Wound Therapy in the Management of Pressure Ulcers

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Science and Practice of Pressure Ulcer Management

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Abstract

The mechanisms of action of negative pressure wound therapy (NPWT) has shown specific effects including removal of excess fluid and improving wound bed circulation, reducing bacterial load, promoting cell proliferation and synthesis, increasing the level of angiogenic and stimulatory cytokines, and endothelial cell mobilization. These effects, as predicated by the adequate delivery of negative pressure to the wound site, are translated into clinical outcomes such as improved tissue perfusion, reduced tissue edema, and increased granulation tissue formation. The scientific foundation for NPWT forms the basis for the improved patient outcomes observed in the published clinical literature and supports its use for temporizing wounds and protecting them from external contamination during long-term care.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Santa Chiara Hospital, University of Pisa, Pisa, Italy

    Valentina Dini, Salvatore Panduri & Marco Romanelli

Authors
  1. Valentina Dini
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  2. Salvatore Panduri
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  3. Marco Romanelli
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Editor information

Editors and Affiliations

  1. Department of Dermatology, Santa Chiara Hospital, University of Pisa, Pisa, Italy

    Marco Romanelli

  2. Welsh Wound Innovation Centre, Rhondda Cynon Taf Wales, United Kingdom

    Michael Clark

  3. Department of Biomedical Engineering, Faculty of Engineering Tel Aviv University, Tel Aviv, Israel

    Amit Gefen

  4. Bambino Gesuʼ Childrenʼs Hospital, Rome, Italy

    Guido Ciprandi

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Dini, V., Panduri, S., Romanelli, M. (2018). Negative Pressure Wound Therapy in the Management of Pressure Ulcers. In: Romanelli, M., Clark, M., Gefen, A., Ciprandi, G. (eds) Science and Practice of Pressure Ulcer Management. Springer, London. https://doi.org/10.1007/978-1-4471-7413-4_14

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  • DOI: https://doi.org/10.1007/978-1-4471-7413-4_14

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-7411-0

  • Online ISBN: 978-1-4471-7413-4

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