Abstract
Transcatheter patent foramen ovale closure has evolved into one of the most commonly performed structural interventions worldwide. Although the prevalence of patent foramen ovale may even be greater in children than adults, closure is rarely performed in this group despite susceptibility to similar defect-related morbidity. Despite an association with arterial ischemic stroke in approximately 5 % of cases and an overall stroke recurrence rate of 20 %, proof that device closure is superior to medical therapy will be significantly more challenging to prove than it has been in adult patients. Therefore as with many circumstances in interventional pediatric cardiology, treatment of patent foramen ovale in children lacks supportive data and practice varies considerably. This chapter will outline some of the indications for closure in a pediatric population, methods to circumvent some of the diagnostic challenges and a technical approach to closure in this age group.
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References
Pesonen E, Haavisto H, Ammälä P, Teramo K. Intrauterine hydrops caused by premature closure of the foramen ovale. Arch Dis Child. 1983;58:1015–6.
Wang NK, Shen CT, Lin MS. Results of echocardiographic screening in 10,000 newborns. Acta Paediatr Taiwan. 2007;48:7–9.
Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc. 1984;59:17–20.
Homma S, Sacco RL. Patent foramen ovale and stroke. Circulation. 2005;112:1063–72.
Giannopoulos A, Gavras C, Sarioglou S, Agathagelou F, Kassapoglou I, Athanassiadou F. Atrial septal aneurysms in childhood: prevalence, classification, and concurrent abnormalities. Cardiol Young. 2013;7:1–6.
Fullerton HJ, Wu YW, Zhao S, Johnston SC. Risk of stroke in children: ethnic and gender disparities. Neurology. 2003;61:189–94.
Chung B, Wong V. Pediatric stroke among Hong Kong Chinese subjects. Pediatrics. 2004;114:206–12.
De Veber GA, MacGregor D, Curtis R, Mayank S. Neurologic out- come in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol. 2000;15:316–24.
Zahuranec DB, Brown DL, Lisabeth LD, Morgenstern LB. Is it time for a large, collaborative study of pediatric stroke? Stroke. 2005;36:1825–9.
Strater R, Becker S, von Eckardstein A, et al. Prospective assessment of risk factors for recurrent stroke during childhood—a 5- year follow-up study. Lancet. 2002;360:1540–5.
Brankovic-Sreckovic V, Milic-Rasic V, Jovic N, et al. The recurrence risk of ischemic stroke in childhood. Med Princ Pract. 2004;13:153–8.
Darteyre S, Chabrier S, Presles E, et al. Lack of progressive arteriopathy and stroke recurrence among children with cryptogenic stroke. Neurology. 2012;79:2342–8.
Benedik MP, Zaletel M, Meglic NP, Podnar T. A right-to-left shunt in children with arterial ischaemic stroke. Arch Dis Child. 2011;96:461–7.
Bogousslavsky J, Garazi S, Jeanrenaud X, Aebischer N, Van Melle G. Stroke recurrence in patients with patent foramen ovale: the Lausanne Study. Lausanne Stroke with Paradoxal Embolism Study Group. Neurology. 1996;46:1301–5.
Barnes C, Deveber G. Prothrombotic abnormalities in childhood ischaemic stroke. Thromb Res. 2006;118:67–74.
Kenny D, Turner M, Martin R. When to close a patent foramen ovale. Arch Dis Child. 2008;93:255–9.
Butera G, Lucente M, Rosti L, et al. A comparison between the early and mid-term results of surgical as opposed to percutaneous closure of defects in the oval fossa in children aged less than 6 years. Cardiol Young. 2007;17:35–41.
Dowling MM, Lee N, Quinn CT, et al. Prevalence of intracardiac shunting in children with sickle cell disease and stroke. J Pediatr. 2010;156:645–50.
Carano N, Agnetti A, Hagler DJ, Tchana B, Squarcia U, Bernasconi S. Acute myocardial infarction in a child: possible pathogenic role of patent foramen ovale associated with heritable thrombophilia. Pediatrics. 2004;114:e255–8.
Mavromichalis I, Anagnostopoulos D, Metaxas N, et al. Prevalence of migraine in schoolchildren and some clinical comparisons between migraine with and without aura. Headache. 1999;39:728–36.
McCandless RT, Arrington CB, Nielsen DC, Bale Jr JF, Minich LL. Patent foramen ovale in children with migraine headaches. J Pediatr. 2011;159:243–7.
Dowson A, Mullen MJ, Peatfield R, et al. Migraine Intervention With STARFlex Technology (MIST) trial: a prospective, multicenter, double-blind, sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache. Circulation. 2008;117:1397–404.
Lemka M, Pienczk-Reclawowicz K, Pilarska E, Szmuda M. Cessation of sporadic hemiplegic migraine attacks after patent foramen ovale closure. Dev Med Child Neurol. 2009;51:923–4.
Wilmshurst PT, Byrne JC, Webb-Peploe MM. Relation between interatrial shunts and decompression sickness in divers. Lancet. 1989;2:1302–6.
Wilmshurst P, Bryson P. Relationship between the clinical features of decompression illness and its causes. Clin Sci. 2000;99:65–75.
Knauth M, Ries S, Pohimann S, et al. Cohort study of multiple brain lesions in sport divers: role of patent foramen ovale. BMJ. 1997;314:701–5.
Kenny D, Turner M, Martin R. PFO closure in children. Catheter Cardiovasc Interv. 2008;71:715.
Dalvi B, Pinto R, Gupta A. Device closure of large atrial septal defects requiring devices > or =20 mm in small children weighing < 20 kg. Catheter Cardiovasc Interv. 2008;71:679–86.
Hornung M, Bertog SC, Franke J, et al. Long-term results of a randomized trial comparing three different devices for percutaneous closure of a patent foramen ovale. Eur Heart J. 2013;34:3362–9.
Thaman R, Faganello G, Gimeno JR, et al. Efficacy of percutaneous closure of patent foramen ovale: comparison among three commonly used occluders. Heart. 2011;97:394–9.
Amin Z, Hijazi ZM, Bass JL, Cheatham JP, Hellenbrand W, Kleinman CS. PFO closure complications from the AGA registry. Catheter Cardiovasc Interv. 2008;72:74–9.
Benedik MP, Zaletel M, Meglic NP, Podnar T. Patent foramen ovale and unexplained ischemic cerebrovascular events in children. Catheter Cardiovasc Interv. 2007;70:999–1007.
Bartz PJ, Cetta F, Cabalka AK, et al. Paradoxical emboli in children and young adults: role of atrial septal defect and patent foramen ovale device closure. Mayo Clin Proc. 2006;81:615–8.
Agnetti A, Carano N, Sani E, et al. Cryptogenic stroke in children: possible role of patent foramen ovale. Neuropediatrics. 2006;​37:53–6.
Thomson JD, Hildick-Smith D, Clift P, et al. Patent foramen ovale closure with the Gore Septal Occluder (GSO); initial UK experience. Catheter Cardiovasc Interv. 2014;83:467–73.
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Kenny, D. (2015). Optimal Device for Children and Closure Indications in Pediatric Population. In: Amin, Z., Tobis, J., Sievert, H., Carroll, J. (eds) Patent Foramen Ovale. Springer, London. https://doi.org/10.1007/978-1-4471-4987-3_19
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DOI: https://doi.org/10.1007/978-1-4471-4987-3_19
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