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Animal Research in Pediatric Cardiology and Cardiac Surgery

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Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

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Abstract

Experimental animal models are often part of the process to develop new methods, devices, or discoveries in modern medical science, and choosing the right model is key to the success of any project. The object of animal models is to reproduce human diseases, metabolically and pathophysiologically, to help provide answers of disease pathogenesis, prevention, and treatment. When carrying out any experimental surgical procedure, appropriate anesthesia and effective analgesia (pain control) are essential to minimize the likelihood of pain or distress in the animals being studied. This chapter aims at providing basic tools for the nonanimal specialist in order to make the right choice, to learn the introductory principles of laboratory animal anesthesia, and to appreciate factors that can affect the data obtained, while understanding the social and ethical issues involved in the use of animals in biomedical research.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Children’s Hospital Colorado University of Colorado Denver & Health Sciences Center Denver, 13123 East 16th Avenue, 100, Aurora, 80045, CO, USA

    Suzanne Osorio-da Cruz

  2. Comparative Biology Centre, The Medical School, University of Newcastle, Newcastle upon Tyne, UK

    Paul Flecknell

  3. Medical School, Framlington Place, Institute for Neuroscience Henry Wellcome Building, Newcastle upon Tyne, UK

    Claire Richardson

Authors
  1. Suzanne Osorio-da Cruz
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  2. Paul Flecknell
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  3. Claire Richardson
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Corresponding author

Correspondence to Suzanne Osorio-da Cruz .

Editor information

Editors and Affiliations

  1. Dept. of Pediatric Cardiology, Children's Hospital Colorado, Univ. of Colorado, Denver, Aurora, Colorado, USA

    Eduardo M. Da Cruz

  2. Dept. Pediatric Cardiology, Children's Hospital Colorado, Univ. of Colorado, Denver, Aurora, Colorado, USA

    Dunbar Ivy

  3. Pediatric Cardiac Surgery, Children's Hospital Colorado, Univ. of Colorado, Denver, Aurora, Colorado, USA

    James Jaggers

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Cruz, S.Od., Flecknell, P., Richardson, C. (2014). Animal Research in Pediatric Cardiology and Cardiac Surgery. In: Da Cruz, E., Ivy, D., Jaggers, J. (eds) Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. Springer, London. https://doi.org/10.1007/978-1-4471-4619-3_65

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  • DOI: https://doi.org/10.1007/978-1-4471-4619-3_65

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4618-6

  • Online ISBN: 978-1-4471-4619-3

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