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The Molecular Basis of Joint Hypermobility

  • Chapter
Hypermobility of Joints

Abstract

The ability of joints to undergo repeated and rapid movements is attributable to the unique mechanical properties of the extracellular matrix (ECM) of the joint capsule and surrounding ligaments and tendons. A delicate balance exists between “stiffness” and “elasticity” of these tissues. Stiffness comes from very long collagen fibrils, which are arranged in parallel bundles in the ECM. These fibrils resist pulling forces and are the primary source of the mechanical strength of tissues. Elasticity originates from the crimping of collagen fibrils, but mostly, from the fibrillin- and elastin-containing microfibrils in the ECM. These elastic fibres have an unique arrangement of macromolecules that permits extension and contraction at a molecular level. An understanding of the molecular and structural basis of joint hypermobility requires a detailed knowledge of the structure, function and organisation of the collagenous and elastic polymer systems that comprise the ECM.

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Authors and Affiliations

  1. Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK

    Gillian Wallis

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  1. Karl Kadler
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  2. Gillian Wallis
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© 1999 Springer-Verlag London

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Kadler, K., Wallis, G. (1999). The Molecular Basis of Joint Hypermobility. In: Hypermobility of Joints. Springer, London. https://doi.org/10.1007/978-1-4471-3633-0_3

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  • DOI: https://doi.org/10.1007/978-1-4471-3633-0_3

  • Publisher Name: Springer, London

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