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Magnetoencephalography, Functional Connectivity, and Neural Network Topology in Diffuse Low-Grade Gliomas

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Diffuse Low-Grade Gliomas in Adults

Abstract

Structural as well as functional connectivity of the cerebral network may be affected by the presence of a brain tumor. Magnetoencephalography (MEG) is one of the methods to study functional connectivity. Within predefined, classical frequency bands, various resting-state network characteristics can be studied. These characteristics enable us to describe a network in terms of synchronization, clustering coefficient, and so-called small worldness. These phenomena appear to be correlated with cognitive functioning and with the occurrence of epileptic seizures in low-grade glioma patients. A better understanding of the relation between the presence of a glioma and the disruption of the neural network will in the future contribute to the planning of surgery and will make it possible to study neural plasticity.

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References

  1. Aertsen AM, Gerstein GL, Habib MK, Palm G. Dynamics of neuronal firing correlation: modulation of “effective connectivity”. J Neurophysiol. 1989;61:900–17.

    PubMed  CAS  Google Scholar 

  2. Bullmore E, Sporns O. Complex brain networks: graph theoretical analysis of structural and functional systems. Nature. 2009;10:186–98.

    CAS  Google Scholar 

  3. Pallud J, Varlet P, Devaux B, Geha S, Badoual M, Deroulers C, Page P, Dezamis E, Daumas-Duport C, Roux FX. Diffuse low-grade oligodendrogliomas extend beyond MRI-defined abnormalities. Neurology. 2010;74:1724–31.

    Article  PubMed  CAS  Google Scholar 

  4. Yordanova YN, Moritz-Gasser S, Duffau H. Awake surgery for WHO Grade II gliomas within “noneloquent” areas in the left dominant hemisphere: toward a “supratotal” resection. J Neurosurg. 2011;115:232–9.

    Article  PubMed  Google Scholar 

  5. Martino J, Honma SM, Findlay AM, Guggisberg AG, Owen JP, Kirsch HE, Berger MS, Nagarajan SS. Resting functional connectivity in patients with brain tumors in eloquent areas. Ann Neurol. 2011;69:521–32.

    Article  PubMed  Google Scholar 

  6. Sporns O. From simple graphs to the connectome: networks in neuroimaging. Neuroimage. 2012;62(2):881–6.

    Article  PubMed  Google Scholar 

  7. Tijms BM, Seriès P, Wilshaw DJ, Lawrie SM. Similarity-based extraction of individual networks from gray mather MRI scans. Cereb Cortex. 2012;22(7):1530–41.

    Article  PubMed  Google Scholar 

  8. Hillebrand A, Barnes GR, Bosboom JL, Berendse HW, Stam CJ. Frequency-dependent functional connectivity within resting-state networks: an atlas-based MEG beamformer solution. Neuroimage. 2011;59(4):3909–21.

    Article  PubMed  Google Scholar 

  9. Hillebrand A, Barnes GR. Practical constraints on estimation of source extent with MEG beamformers. Neuroimage. 2011;54(4):2732–40.

    Article  PubMed  Google Scholar 

  10. Schreiber A, Hubbe U, Ziyeh S, Hennig J. The influence of glioma and nonglial space-occupying lesion on blood-oxygen-level-dependent contrast enhancement. AJNR Am J Neuroradiol. 2000;21:1055–63.

    PubMed  CAS  Google Scholar 

  11. Stippich C, Freitag P, Kassubek J, Sörös P, Kamada K, Kober H, Scheffler K, Hopfengärtner R, Bilecen D, Radü EW, Vieth JB. Motor, somatosensory and auditory cortex localization by fMRI and MEG. Neuroreport. 1998;9:1953–7.

    Article  PubMed  CAS  Google Scholar 

  12. Stam CJ, van Dijk BW. Synchronization likelihood: an unbiased measure of generalized synchronization in multivariate data sets. Physica D. 2002;163:236–41.

    Article  Google Scholar 

  13. Stam CJ, van Cappellen van Walsum AM, Micheloyannis S. Variability of EEG synchronization during a working memory task in healthy subjects. Int J Psychophysiol. 2002;46:53–66.

    Article  PubMed  Google Scholar 

  14. Bartolomei F, Bosma I, Klein M, Baayen JC, Reijneveld JC, Postma TJ, Heimans JJ, van Dijk BW, de Munck JC, de Jongh A, Cover KS, Stam CJ. How do brain tumors alter functional connectivity? A magnetoencephalography study. Ann Neurol. 2006;59:128–38.

    Article  PubMed  Google Scholar 

  15. Klein M, Heimans JJ, Aaronson NK, van der Ploeg HM, Grit J, Muller M, Postma TJ, Mooij JJ, Boerman RH, Beute GN, Ossenkoppele GJ, van Imhoff GW, Dekker AW, Jolles J, Slotman BJ, Struikmans H, Taphoorn MJ. Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study. Lancet. 2002;360:1361–8.

    Article  PubMed  CAS  Google Scholar 

  16. Klein M, Engelberts NH, van der Ploeg HM, Kasteleijn-Nolst Trenité DG, Aaronson NK, Taphoorn MJ, Baaijen JH, Vandertop WP, Muller M, Postma TJ, Heimans JJ. Epilepsy in low-grade gliomas: the impact on cognitive function and quality of life. Ann Neurol. 2003;54:514–20.

    Article  PubMed  Google Scholar 

  17. Bartolomei F, Bosma I, Klein M, Baayen JC, Reijneveld JC, Postma TJ, Heimans JJ, van Dijk BW, de Munck JC, de Jongh A, Cover KS, Stam JC. Disturbed functional connectivity in brain tumour patients: evaluation by graph analysis of synchronization matrices. Clin Neurophys. 2006;117:2039–49.

    Article  Google Scholar 

  18. Stam CJ, Jones BF, Nolte G, Breakspear M, Scheltens P. Small-world networks and functional connectivity in Alzheimer’s disease. Cereb Cortex. 2007;17(1):92–9.

    Article  PubMed  CAS  Google Scholar 

  19. Stam CJ, Reijneveld JC. Graph theoretical analysis of complex networks in the brain. Nonlinear Biomed Phys. 2007;1:3.

    Article  PubMed  Google Scholar 

  20. Halgren E, Boujon C, Clarke J, Wang C, Chauvel P. Rapid distributed fronto-parieto-occipital processing stages during working memory in humans. Cereb Cortex. 2002;12:710–28.

    Article  PubMed  CAS  Google Scholar 

  21. Watts DJ, Strogatz SH. Collective dynamics of ‘small-world’ networks. Nature. 1998;393:440–2.

    Article  PubMed  CAS  Google Scholar 

  22. Sporns O, Chialvo DR, Kaiser M, Hilgetag CC. Organization, development and function of complex brain networks. Trends Cogn Sci. 2004;8:418–25.

    Article  PubMed  Google Scholar 

  23. Heimans JJ, Reijneveld JC. Factors affecting the cerebral network in brain tumor patients. J. Neurooncol 2012;108:231–7.

    Google Scholar 

  24. Humphries MD, Gurney K. Network ‘small-world-ness’: a quantitative method for determining canonical network equivalence. PLoS One. 2008;3(4):e0002051.

    Article  PubMed  Google Scholar 

  25. Douw L, Schoonheim MM, Landi D, van der Meer ML, Geurts JJG, Reijneveld JC, Klein M, Stam CJ. Cognition is related to resting-state small-world network topology: an magnetoencephalographic study. Neuroscience. 2011;175:169–77.

    Article  PubMed  CAS  Google Scholar 

  26. Van den Heuvel MP, Stam CJ, Kahn RS, Hulshoff Pol HE. Efficiency of functional brain networks and intellectual performance. J Neurosci. 2009;29(23):7619–24.

    Article  PubMed  Google Scholar 

  27. Douw L, Baayen JC, Bosma I, Klein M, Vandertop WP, Heimans JJ, Stam CJ, de Munck JC, Reijneveld JC. Treatment-related changes in functional connectivity in brain tumor patients: a magnetoencephalography study. Exp Neurol. 2008;212(2):285–90.

    Article  PubMed  Google Scholar 

  28. Stam CJ, Jones BF, Manshanden I, van Cappellen van Walsum AM, Montez T, Verbunt JP, de Munck JC, van Dijk BW, Berendse HW, Scheltens P. Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer’s disease. Neuroimage. 2006;32(3):1335–44.

    Article  PubMed  CAS  Google Scholar 

  29. Stam CJ, Nolte G, Daffartshofer A. Phase lag index: assessment of functional connectivity from multi channel EEG and MEG with diminished bias from common sources. Hum Brain Map. 2007;28(11):1178–93.

    Article  Google Scholar 

  30. Bosma I, Douw L, Bartolomei F, Heimans JJ, van Dijk BW, Postma TJ, Stam CJ, Reijneveld JC, Klein M. Synchronized brain activity and neurocognitive function in patients with low-grade glioma: a magnetoencephalography study. Neuro Oncol. 2008;10:734–44.

    Article  PubMed  Google Scholar 

  31. Bosma I, Reijneveld JC, Klein M, Douw L, van Dijk BW, Heimans JJ, Stam CJ. Disturbed functional brain networks and neurocognitive function in low-grade glioma patients: a graph theoretical analysis of resting-state MEG. Nonlinear Biomed Phys. 2009;3:9.

    Article  PubMed  Google Scholar 

  32. Ganslandt O, Fahlbusch R, Nimsky C, Kober H, Möller M, Steinmeier R, Romstöck J, Vieth J. Functional neuronavigation with magnetoencephalography: outcome in 50 patients with lesions around the motor cortex. J Neurosurg. 1999;91:73–9.

    Article  PubMed  CAS  Google Scholar 

  33. Schiffbauer H, Berger MS, Ferrari P, Freudenstein D, Rowley HA, Roberts TPL. Preoperative magnetic source imaging for brain tumor surgery: a quantitative comparison with intraoperative sensory and motor mapping. J Neurosurg. 2002;97:1333–42.

    Article  PubMed  Google Scholar 

  34. Guggisberg AG, Honma SM, Findlay AM, Dalal SS, Kirsch HE, Berger MS, Nagarajan SS. Mapping functional connectivity in patients with brain lesions. Ann Neurol. 2008;63:193–203.

    Article  PubMed  Google Scholar 

  35. Duffau H, Thiebaut de Schotten M, Mandonnet E. White matter functional connectivity as an additional landmark for dominant temporal lobectomy. J Neurol Neurosurg Psychiatry. 2008;79:492–5.

    Article  PubMed  CAS  Google Scholar 

  36. Duffau H. Surgery of low-grade gliomas: towards a ‘functional neurooncology’. Curr Opin Oncol. 2009;21:543–9.

    Article  PubMed  Google Scholar 

  37. Englot DJ, Berger MS, Barbaro NM, Chang EF. Predictors of seizure freedom after resection of supratentorial low-grade gliomas. J Neurosurg. 2011;115:240–4.

    Article  PubMed  Google Scholar 

  38. Kalitzin S, Velis D, Suffczynski P, Para J, da Silva FL. Electrical brain-stimulation paradigm for estimating the seizure onset site and the time to ictal transition in temporal lobe epilepsy. Clin Neurophysiol. 2005;116:718–28.

    Article  PubMed  CAS  Google Scholar 

  39. Ponten SC, Bartolomei F, Stam CJ. Small-world networks and epilepsy: graph theoretical analysis of intracerebrally recorded mesial temporal lobe seizures. Clin Neurophysiol. 2007;118:918–27.

    Article  PubMed  CAS  Google Scholar 

  40. Morgan RJ, Soltesz I. Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proc Natl Acad Sci USA. 2008;105:6179–84.

    Article  PubMed  CAS  Google Scholar 

  41. Wendling F, Hernandez A, Bellanger JJ, Chauvel P, Bartolomei GF. Interictal to ictal transition in human temporal lobe epilepsy: insights from a computational model of intracerebral EEG. J Clin Neurophysiol. 2005;22:343–56.

    PubMed  Google Scholar 

  42. Chavez M, Hwang DU, Amann A, Boccaletti S. Synchronizing weighted complex networks. Chaos. 2006;16:015106.

    Article  PubMed  CAS  Google Scholar 

  43. Vlooswijk MCG, Vaessen MJ, Jansen JFA, de Krom MCFTM, Majoie HJM, Hofman PAM, Aldenkamp AP, Backes WH. Loss of network efficiency associated with cognitive decline in chronic epilepsy. Neurology. 2011;77:938–44.

    Article  PubMed  CAS  Google Scholar 

  44. Meador KJ. Networks, cognition, and epilepsy. Neurology. 2011;77:930–1.

    Article  PubMed  Google Scholar 

  45. Douw L, van Dellen E, de Groot M, Heimans JJ, Klein M, Stam CJ, Reijneveld JC. Epilepsy is related to theta band brain connectivity and network topology in brain tumor patients. BMC Neurosci. 2010;11:103.

    Article  PubMed  Google Scholar 

  46. Vulliemoz S, Lemieux L, Daunizeau J, Michel CM, Duncan JS. The combination of EEG source imaging and EEG-correlated functional MRI to map epileptic networks. Epilepsia. 2010;51:491–505.

    Article  PubMed  Google Scholar 

  47. Duffau H. Lessons from brain mapping in surgery for low-grade glioma: insights into associations between tumour and brain plasticity. Lancet Neurol. 2005;4:476–86.

    Article  PubMed  Google Scholar 

  48. Duffau H, Capelle L, Denvil D, Sichez N, Gatignol P, Lopes M, Mitchell MC, Sichez JP, Van Effenterre R. Functional recovery after surgical resection of low-grade gliomas in eloquent brain: hypothesis of brain compensation. J Neurol Neurosurg Psychiatry. 2003;74:901–7.

    Article  PubMed  CAS  Google Scholar 

  49. Stam CJ, Hillebrand A, Wang H, van Mieghem P. Emergence of modular structure in a large-scale brain network with interaction between dynamics and connectivity. Front Comput Neurosci. 2010;24(4): p 133.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands

    Jan J. Heimans MD, PhD & Jaap C. Reijneveld MD, PhD

  2. Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, 7057, 1007, MB, Amsterdam, The Netherlands

    Cornelis J. Stam MD, PhD

Authors
  1. Jan J. Heimans MD, PhD
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  2. Jaap C. Reijneveld MD, PhD
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  3. Cornelis J. Stam MD, PhD
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Correspondence to Jan J. Heimans MD, PhD .

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Editors and Affiliations

  1. , INSERM U1051, Institute for Neurosciences of Montpelli, av. Augustin Fliche 80, Montpellier, 34295, France

    Hugues Duffau

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Heimans, J.J., Reijneveld, J.C., Stam, C.J. (2013). Magnetoencephalography, Functional Connectivity, and Neural Network Topology in Diffuse Low-Grade Gliomas. In: Duffau, H. (eds) Diffuse Low-Grade Gliomas in Adults. Springer, London. https://doi.org/10.1007/978-1-4471-2213-5_21

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  • DOI: https://doi.org/10.1007/978-1-4471-2213-5_21

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  • Online ISBN: 978-1-4471-2213-5

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