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Abstract

Osteoma is an absolutely benign bone lesion that may arise within a bone or the periosteum. This is a lesion that can grow like a tumor or can be a local reaction, with osseous overgrowth from trauma, infection or an invading tumor such as a meningioma. Therefore osteoma as a true bone tumor is debatable, and some authors have considered it to be a hamartoma of bone or the sclerotized end stage of fibrous bone dysplasia. In cases of an obviously solitary tumor growth it is a benign lesion consisting of well-differentiated mature bone of compact or spongiosal type,with very slow growth. This leads to a continuous deformation of the involved bone area and may cause symptoms such as pain or nerval compression. Consequently, the lesions have to be removed operatively.

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Literature

  • Adler CP. Parosteal (juxtacortical) osteosarcoma of the distal femur. Pathol Res Pract 1980; 169: 388–95

    Article  PubMed  CAS  Google Scholar 

  • Adler CP, Schmidt A. Aneurysmale Knochenzyste des Femurs mit malignem Verlauf. Verh Dtsch Ges Pathol 1978; 62: 487

    PubMed  CAS  Google Scholar 

  • Adler CP, Uehlinger E. Grenzfälle bei.Knochentumoren. Präneoplatische Veränderungen und Geschwülste fraglicher Dignität. Verh Dtsch Ges Pathol 1979; 63: 352–8

    Google Scholar 

  • Atik OS, Caglar M, Bölükbase S, Gögüs S, Gögüs MT. Osteogenic sarcoma of the distal femur in a young child. Hum Pathol 1982; 13: 766

    Article  PubMed  CAS  Google Scholar 

  • Ayala AG, Raymond AK, Jaffe N. The pathologist’s role in the diagnosis and treatment of osteosarcomas in children. Human Pathol 1984; 15: 258–66

    Article  CAS  Google Scholar 

  • Baum PA, Nelson MC, Lack EE, Bogumill GP. Parosteal osteoma of the tibia. Skeletal Radiol 1989;18:406–9 Bertoni F, Unni KK, McLeod RA, Dahlin DC. Osteosarcoma resembling osteoblastoma. Cancer 1985; 55: 416–26

    Article  Google Scholar 

  • Bilbao JI, Martin Algarra S, Martinez de Negri J, Lecumberri F, Longo J, Sierrasesumaga L, et al. Osteosarcoma: correlation ’ between radiological and histological changes after intra-arterial chemotherapy. Eur J Radiol 1990; 11: 98–103

    Article  PubMed  CAS  Google Scholar 

  • Brodeur GM, Caces J, Willians DL, Look TA, Pratt CB. Osteosarcoma, fibrous dysplasia, and a chromasomal abnormality in a 3-year-old child. Cancer 1980; 46: 1197–1201

    Article  PubMed  CAS  Google Scholar 

  • Campanacci M, Picci P, Gherlinzoni F, Guerra A, Bertoni F, Neff JR. Parosteal osteosarcoma. J Bone Jt Surg 1984; 66-B:313–21

    CAS  Google Scholar 

  • Camuzard JF, Vaille G, Santini J, Raspaldo H, Demard F. Gardner’s syndrome. Review of the literature. Report of a familial form. Ann Otolaryngol Chir Cervicofac 1990; 107: 509–13

    PubMed  CAS  Google Scholar 

  • Carter TR. Osteoid osteoma of the hip: an alternate method of excision. Orthop Rev 1990; 19: 903–5

    PubMed  CAS  Google Scholar 

  • Carter JR, Abdul-Karim FW. Pathology of childhood osteosarcoma. Perspect Pediatr Pathol 1987; 9: 133–70

    PubMed  CAS  Google Scholar 

  • Crim JR, Mirra JM, Eckardt JJ, Seeger LL. Widespread inflammatory response to osteoblastoma: the flare phenomenon. Radiology 1990; 177: 835–6

    PubMed  CAS  Google Scholar 

  • Dahlin DC, Unni KK. Osteosarcoma of bone and its important recognizable varieties. Am J Surg Pathol 1977; 1: 61–72

    Article  PubMed  CAS  Google Scholar 

  • Delling G, Pompesius-Kempa M, Welkerling H, Dreyer T, Maas R, Heise U, Winkler K. Morphological investigation of tumor growth and distribution of viable tumor areas in osteosarcomas after chemotherapy. Chir Organi Mov 1990; 75: 45–47

    PubMed  CAS  Google Scholar 

  • Dorfman HD, Weiss SW. Borderline osteoblastic tumors: problems in the differential diagnosis of aggressive osteoblastoma and low-grade osteosarcoma. Semin Diagn Pathol 1984; 1: 215–234

    PubMed  CAS  Google Scholar 

  • Dowell JK, Edgar MA. A case report of recurrent osteoblastoma of the rib presenting as painless progressive scoliosis. Spine 1990; 15: 141–2

    Article  PubMed  CAS  Google Scholar 

  • Enneking WF, Kagan A. “Skip” metastases in osteosarcoma. Cancer 1975; 36: 2192–205

    Article  PubMed  CAS  Google Scholar 

  • Enneking WF, Spanier SS, Goodman MA. The surgery of musculoskeletal sarcoma. J Bone Jt Surg 1980;62-A: 1027–30

    CAS  Google Scholar 

  • Giangaspero F, Stracca V, Visona A, Eusebi V. Small-cell osteosarcoma of the mandible. Case report. Appl Pathol 1984; 2: 28–31

    PubMed  CAS  Google Scholar 

  • Goorin AM, Abelson HT, Frei III E. Osteosarcoma: fifteen years later. N Engl J Med 1985; 313: 1637–43

    Article  PubMed  CAS  Google Scholar 

  • Grigo B, Blau HJ. Neuroblastoma, nephroblastoma and osteosarcoma in patients at 2 pediatric oncologic centers. A 15-year report. Arch Geschwulstforsch 1990; 60: 365–72

    CAS  Google Scholar 

  • Hall RB, Robinson LH, Malawar MM, Dunham WK. Periosteal osteosarcoma. Cancer 1985; 55: 165–71

    Article  PubMed  CAS  Google Scholar 

  • Haug RH, Hauer C, Camillo AJ, Araneta M. Benign osteoblastoma of the mandible: report of a case. J Oral Maxillofac Surg 1990; 48: 743–8

    Article  PubMed  CAS  Google Scholar 

  • Heymer B, Kreidler J, Adler CP. Strahleninduziertes Osteosarkom des Unterkiefers. Dtsch Z Mund Kiefer Gesichtschir 1988; 12: 113–19

    PubMed  CAS  Google Scholar 

  • Hochstetter von AR. Spontaneous necrosis in osteosarcomas. Chir Organi Mov 1990; 75: 32–5

    Google Scholar 

  • Hopper KD, Haseman DB, Moser RP Jr, Sweet DE, Madewell JE. Osteosarcomatosis (Case report). Skeletal Radiol 1990; 19: 535–7

    Article  PubMed  CAS  Google Scholar 

  • Huvos AG. Clinicopathologic spectrum of osteogenic sarcoma. — Recent observations. Pathol Anat 1979; 14: 123–44

    Google Scholar 

  • Huvos AG, Rosen G, Bretsky SS, Butler A. Teleangiectatic osteogenic sarcoma. — A clinicopathologic study of 124 patients. Cancer 1982; 49: 1679–89

    Article  PubMed  CAS  Google Scholar 

  • Irnberger TH. Infantiles Osteoid-Osteom der Tibia. — Röntgenologische and computertomographische Diagnose and Differentialdiagnose. Wien Med Wochenschr 1983; 3: 67–71

    Google Scholar 

  • Jackson JR, Bell MEA. Spurious “benign osteoblastoma”. J Bone Jt Surg 1977;59-A:397–401

    CAS  Google Scholar 

  • Kavanagh TG, Cannon SR, Pringle J, Stoker DJ, Kemp HB. Parosteal osteosarcoma. Treatment by wide resection and prosthetic replacement. J Bone Jt Surg 1990;B-72:959–65

    CAS  Google Scholar 

  • Kozakewich H, Perez-Atayde AR, Goorin AM, Wilkinson RH, Gebhardt MC, Vawter GF. Osteosarcoma in young children. Cancer 1991; 67: 638–42

    Article  PubMed  CAS  Google Scholar 

  • Kroon HM, Schurmans J. Osteoblastoma: clinical and radiologic findings in 98 new cases. Radiology 1990; 175: 783–90

    PubMed  CAS  Google Scholar 

  • Lacheretz M, Herbaux B, Hossein-Foucher C, Lecouffe P, Richir M. Détection isotopique pré-operatoire dans le traitement de l’osteome ostéoide chez l’enfant. Chirurgie 1989; 115: 413–16

    PubMed  CAS  Google Scholar 

  • Levine E, DeSmet AA, Huntrakoon M. Juxtacortical osteosarcoma. A radiologic and histologic spectrum. Skeletal Radiol 1985; 14: 38–46

    Article  PubMed  CAS  Google Scholar 

  • Levy ML, Jaffe N. Osteosarcoma in early childhood. Pediatrics 1982; 70: 302–3

    PubMed  CAS  Google Scholar 

  • López-Barea F, Contreras F, Sanchez-Herrera S. Grade III conventional sclerosing osteosarcoma of the calcaneus. Skeletal Radiol 1989; 18: 237–40

    Article  PubMed  Google Scholar 

  • Lowbeer L. Multifocal osteosarcomatosis — a rare entity. Bull Pathol 1968; 9: 52–3

    Google Scholar 

  • Marin SF, Dwyer A, Kissane JM, Costa J. Small-cell osteosarcoma. Cancer 1982; 50: 990–6

    Article  Google Scholar 

  • Marsh BW, Bonfiglio M, Brady LP, Enneking WF. Benign osteoblastoma: Range of manifestations. J Bone Jt Surg 1975;57-A:1–9

    CAS  Google Scholar 

  • Matsuno T, Unni KK, McLeod RA, Dahlin DC. Teleangiectatic osteogenic sarcoma. Cancer (Phil) 1976; 38: 2538–47

    Article  CAS  Google Scholar 

  • McCarthy EF, Matsuno T, Dorfman HD. Malignant fibrous histiocytoma of bone: a study of 35 cases. Human Pathol 1979; 10: 57–70

    Article  CAS  Google Scholar 

  • McLeod RA, Dahlin DC, Beabout JW. The spectrum of osteoblastoma. Am J Roentgenol 1976; 126: 321–35

    CAS  Google Scholar 

  • Mirra JM, Kendrick RA, Kendrick RE. Pseudomalignant osteoblastoma versus arrested osteosarcoma: a case report. Cancer (Phil) 1976; 37: 2005–14

    Article  CAS  Google Scholar 

  • Mitchell ML, Ackerman LV. Metastatic and pseudo-malignant osteoblastoma: a report of two unusual cases. Skeletal Radiol 1986; 15: 213–18

    Article  PubMed  CAS  Google Scholar 

  • Mohr VD, Bauer T, Schmitt B. Osteoid osteoma at the end of the phalanx of the big toe. Dtsch Med Wochenschr 1990; 115: 1470–4

    Article  PubMed  CAS  Google Scholar 

  • Moss CS, Williams C, Burton IE, Gaba AR. Osteoblastic osteosarcoma of the navicular. Skeletal Radiol 1989; 18: 70–4

    Article  PubMed  CAS  Google Scholar 

  • Parham DM, Pratt CB, Parvey LS, Webber BL, Champion J. Childhood multifocal osteosarcoma. Clinicopathologic and radiologic correlates. Cancer 1985; 55: 2653–8

    Article  PubMed  CAS  Google Scholar 

  • Penman HG, Ring PA. Osteosarcoma in association with total hip replacement. J Bone Jt Surg 1984;B-66:632–4

    CAS  Google Scholar 

  • Picci P, Bacci G, Campanacci M, Gasparini M, Pilotti S, Cerasoli S, et al. Histologic evaluation of necrosis in osteosarcoma included by chemotherapy. Regional mapping of viable and nonviable tumor. Cancer 1985; 56: 1515–21

    Article  PubMed  CAS  Google Scholar 

  • Revell PA, Scholtz CL. Aggressive osteoblastoma. J Pathol 1979; 127: 195–8

    Article  PubMed  CAS  Google Scholar 

  • Roberts P, Davies AM, Starkie CM, Grimer RJ. The nidus of an osteoid osteoma mimicking an os supratrochleare dorsale. Br J Radiol 1990; 63: 899–902

    Article  PubMed  CAS  Google Scholar 

  • Roessner A, Metze K, Heymer B. Aggressive osteoblastoma. Pathol Res Pract 1985; 179: 433–6

    Article  PubMed  CAS  Google Scholar 

  • Ruiter DJ, Cornelisse CJ, van Rijssel TG, van der Velde EA. Aneurysmal bone cyst and teleangiectatic osteosarcoma. A histo-pathological and morphometric study. Virchows Arch [A] 1977; 373: 311–25

    Article  CAS  Google Scholar 

  • Ryan J, Baker L, Benjamin R, Murphy W, Balcerzak S, Gottlieb J. Long-term followup in the cure of osteogenic sarcoma. The Southwest oncology group. Chir Organi Mov 1990; 75: 48–9

    PubMed  CAS  Google Scholar 

  • Sanerkin NG. Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. Cancer 1980;46:178–85 Schajowicz F, Lemos D. Malignant osteoblastoma. J Bone Jt Surg 1976; 58-B:202–11

    Article  Google Scholar 

  • Seki T, Fukuda H, Ishii Y, Hanaoka H, Yatabe S, Takano M, et al. Malignant transformation of benign osteoblastoma. J Bone Jt Surg 1975; 57-A:424–6

    CAS  Google Scholar 

  • Semer LC, Drossner B, Fleming WC, Levin R. Osteoblastoma of the distal phalanx of the hallux. J Foot Surg 1990; 29: 357–60

    PubMed  CAS  Google Scholar 

  • Siegal GP, Dahlin DC, Sim FH. Osteoblastic osteogenic sarcoma in a 35-month old girl. Am J Clin Pathol 1975; 63: 886–90

    PubMed  CAS  Google Scholar 

  • Sim FH, Unni KK, Beabout JW, Dahlin DC. Osteosarcoma with small cells simulating Ewing’s tumor. J Bone Surg (Am) 1979; 61: 207–15

    CAS  Google Scholar 

  • Sim FH, Kurt AM, McLeod RA, Unni KK. Low-grade central osteosarcoma. (Case report). Skeletal Radiol 1990; 19: 457–60

    Article  PubMed  CAS  Google Scholar 

  • Simon MA. Causes of increased survival of patients with osteosarcoma: current controversies. J Bone Jt Surg 1984;66-A:306–10

    Google Scholar 

  • Simon MA, Bos GD. Epiphyseal extension of metaphyseal osteosarcoma in skeletally immature individuals. J Bone Jt Surg 1980;62-A:195–204

    CAS  Google Scholar 

  • Stutch R. Osteoblastoma — a benign entity? Orthop Rev 1975; 4: 27–33

    Google Scholar 

  • Tonai M, Campbell CJ, Ahn GH, Schiller AL, Mankin HJ. Osteoblastoma. Classification and report of 16 patients. Clin Orthop Rel Res 1982; 167: 222–35

    Google Scholar 

  • Triebel HJ, Spielmann RP, Maas R. Unusually localized osteosarcoma. RöFo 1989; 150: 615–16

    PubMed  CAS  Google Scholar 

  • Tsuchiya H, Morikawa S, Tomita K. Osteosarcoma arising from a multiple exostoses lesion: case report. Jpn J Clin Oncol 1990; 20: 296–8

    PubMed  CAS  Google Scholar 

  • Unni KK, Dahlin DC, Beabout JW, Ivins JC. Parosteal osteogenic sarcoma. Cancer (Phil) 1976; 37: 2466–75

    Article  CAS  Google Scholar 

  • Unni KK, Dahlin DC, Beabout JW. Periosteal osteogenic sarcoma. Cancer (Phil) 1976; 37: 2476–2485

    Article  CAS  Google Scholar 

  • Unni KK, Dahlin DC, McCloud RA, Pritchard DJ. Intraosseous well-differentiated osteosarcoma. Cancer 1977; 40: 1337–47

    Article  PubMed  CAS  Google Scholar 

  • Uribe-Botero G, Russell WO, Sutoro WW, Martin RG. Primary osteosarcoma of bone: a clinicopathologic investigation of 243 cases, with necropsystudies in 54. Am J Clin Pathol 1977; 67: 427–35

    PubMed  CAS  Google Scholar 

  • Wang NH, Ma HL, Lo WH, Yang DJ. Osteoid osteoma: clinical and investigative features. Taiwan 1 Hsueh Hui Tsa Chih 1990; 89: 366–72

    CAS  Google Scholar 

  • Williams J, Barret G, Pratt C. Osteosarcoma in 2 very young children. Clin Pediatr (Phil) 1977; 16: 548–51

    Article  Google Scholar 

  • Wold LE, Beabout JW, Unni KK, Prichard DJ. High-grade surface osteosarcomas. Am J Surg Pathol 1984; 8: 181–6

    Article  PubMed  CAS  Google Scholar 

  • Wuisman P, Enneking WF. Prognosis of osteosarcoma with “skip” metastasis. Chir Organi Mov 1990; 75: 60–4

    PubMed  CAS  Google Scholar 

  • Yoshikawa H, Takaoka K, Hamada H, Ono K. Clinical significance of bone morphogenetic activity in osteosarcoma. A study of 20 cases. Cancer 1985; 56: 1682–7

    Article  PubMed  CAS  Google Scholar 

  • Zappia JJ, LaRouere MJ, Telian SA. Massive ossifying fibroma of the temporal bone. Otolaryngol Head—Neck Surg 1990; 103: 480–3

    PubMed  CAS  Google Scholar 

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© 1993 Springer-Verlag London Limited

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Adler, CP., Kozlowski, K. (1993). Tumors of Osteoblastic Origin. In: Primary Bone Tumors and Tumorous Conditions in Children. Springer, London. https://doi.org/10.1007/978-1-4471-1951-7_4

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  • DOI: https://doi.org/10.1007/978-1-4471-1951-7_4

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1953-1

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