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Microenvironmental control of glucocorticoid functions in immune regulation

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Steroid Hormones and the T-Cell Cytokine Profile

Abstract

Lipophilic hormones, including the steroids, thyroid hormones, retinoids, 1,25 dihydroxyvitamin D3, members of the prostaglandin J2 series, and leukotriene B4 represent a diverse group of molecules that can regulate gene expression through a common molecular mechanism. This diverse set of ligands traverse the plasma membrane and bind to ligand-specific intracellular receptors present within the cytosol, perinuclear space, or the nucleus of responsive cell types. Once activated by ligand binding, these intracellular receptors, which are all members of the steroid/nuclear receptor superfamily bind to specific sites on DNA and function as enhancers or repressors of gene transcription [1,2].

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Authors
  1. Jon D. Hennebold
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  2. Raymond A. Daynes
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Editors and Affiliations

  1. Department of Bacteriology, UCL Medical School, Windeyer Building, 46 Cleveland Street, W1P 6DB, London, UK

    G. A. W. Rook

  2. Department of Medicine, Dorothy Hodgkin Crowfoot Laboratories, Bristol Royal Infirmary, Marlborough Street, BS2 8HW, Bristol, UK

    S. Lightman

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Hennebold, J.D., Daynes, R.A. (1997). Microenvironmental control of glucocorticoid functions in immune regulation. In: Rook, G.A.W., Lightman, S. (eds) Steroid Hormones and the T-Cell Cytokine Profile. Springer, London. https://doi.org/10.1007/978-1-4471-0931-0_5

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  • DOI: https://doi.org/10.1007/978-1-4471-0931-0_5

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  • Print ISBN: 978-1-4471-1238-9

  • Online ISBN: 978-1-4471-0931-0

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