Synonyms
Definition
The cell cycle requires dramatic dynamic changes in cellular structures. In order to segregate sister chromatids, a number of cellular processes including centrosome duplication and segregation, establishment of a bipolar spindle, chromosome condensation, and the breakdown of the nuclear envelope need to occur. These processes are directly regulated by several families of protein kinases collectively known as mitotic kinases.
Characteristics
Kinase Families Involved in Mitosis
Cyclin-Dependent Kinases
The relevance of protein kinases in the regulation of the cell cycle became obvious after the pioneer characterization of cyclin-dependent kinase (CDK)1 (Cyclins and Cyclin-Dependent Kinases) (CDC2/CDC28 in yeast) (Cell Cycle, Budding Yeast; Cell Cycle, Fission Yeast). At least 20 CDKs exist in mammals (Malumbres and Barbacid 2005). CDK1 is essential for the G2/M transition (Cell Cycle Transitions, G2/M) and regulates multiple cellular processes...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Archambault V, Glover DM (2009) Polo-like kinases: conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol 10:265–275
Carmena M, Earnshaw WC (2003) The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4:842–854
Goldberg ML (2010) Greatwall kinase protects mitotic phosphosites from barbarian phosphatases. Proc Natl Acad Sci USA 107:12409–12410
Holland AJ, Cleveland DW (2009) Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat Rev Mol Cell Biol 10:478–487
Malumbres M, Barbacid M (2005) Mammalian cyclin-dependent kinases. Trends Biochem Sci 30:630–641
Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8:379–393
Nigg EA (2001) Mitotic kinases as regulators of cell division and its checkpoints. Nat Rev Mol Cell Biol 2:21–32
Nigg EA (2002) Centrosome aberrations: cause or consequence of cancer progression? Nat Rev Cancer 2:815–825
O’Regan L, Blot J, Fry AM (2007) Mitotic regulation by NIMA-related kinases. Cell Div 2:25
Perez de Castro I, de Carcer G, Montoya G, Malumbres M (2008) Emerging cancer therapeutic opportunities by inhibiting mitotic kinases. Curr Opin Pharmacol 8:375–383
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media, LLC
About this entry
Cite this entry
Malumbres, M. (2013). Mitotic Kinases. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_11
Download citation
DOI: https://doi.org/10.1007/978-1-4419-9863-7_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-9862-0
Online ISBN: 978-1-4419-9863-7
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences