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Porphyrin-Based Nanocomposites for Biosensing

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NanoBiosensing

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Porphyrins are an important class of conjugated organic molecules, which can be employed to mimic the active site of many important enzymes, such as hemoglobin, myoglobin, cytochrome c oxidase (CcO), nitric oxide reductase, vitamin B12, and chlorophyll [1–3]. The macrocyclic structure of porphyrin can conjugate many metal elements to form stable metalloporphyrins, which have remarkable photo-, catalytic-, electro-, and biochemical properties. Among these complexes, iron porphyrins can be used well as electron media based on the reversible redox of Fe3+/Fe2+ and exhibit good electrocatalysis to many small molecules related to life processes [4, 5], including dissolved oxygen, NO, neurotransmitters, hydrogen peroxide, and nitrite. On the other hand, high-valent iron(IV)–porphyrin as a strong oxidant has been utilized to catalyze the mono-oxygenation of organic substrates and biomolecules in many chemical reactions [6, 7].

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Authors and Affiliations

  1. Nanjing University, Nanjing, P.R. China

    Huangxian Ju

  2. World Precision Instruments, Inc., Sarasota, FL, USA

    Xueji Zhang

  3. University of Science & Technology, Beijing, P.R. China

    Xueji Zhang

  4. University of California, San Diego, CA, USA

    Joseph Wang

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Ju, H., Zhang, X., Wang, J. (2011). Porphyrin-Based Nanocomposites for Biosensing. In: NanoBiosensing. Biological and Medical Physics, Biomedical Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9622-0_4

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