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Clinical Relevance in a Translational Rodent Model of Acute Ischemic Stroke: Incorporating the Biological Variability of Spontaneous Recanalization

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Translational Stroke Research

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Acute ischemic stroke, in which a clot of blood manages to obstruct an artery supplying blood to a part of the brain and leads to brain damage, ranks as the third leading cause of death and is the leading cause of serious long-term disability in the United States. At present, the administration of the clot-dissolving drug, tissue-plasminogen activator, remains the only FDA-approved reperfusion therapy for acute ischemic stroke. Unfortunately, relatively few people (4–14%, depending on the study) access medical care in time or are eligible enough for treatment to benefit [8,10,24]. There is a need to develop additional therapies. The occlusion that causes a stroke is a dynamic one that is prone to spontaneous re-canalization and varying degrees of spontaneous reperfusion. The incorporation of this tendency into a translational stroke model will maximize clinical relevance.

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  1. Department of Emergency Medicine, University of California, San Diego, CA, USA

    Kama Guluma MD

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Correspondence to Kama Guluma MD .

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  1. , Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA

    Paul A. Lapchak

  2. Loma Linda University, 11234 Anderson Street, Room 2562B, Loma Linda, 92354, California, USA

    John H. Zhang

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Guluma, K. (2012). Clinical Relevance in a Translational Rodent Model of Acute Ischemic Stroke: Incorporating the Biological Variability of Spontaneous Recanalization. In: Lapchak, P., Zhang, J. (eds) Translational Stroke Research. Springer Series in Translational Stroke Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9530-8_26

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