Abstract
The bithorax complex (BX-C) is a set of master control genes that regulates other genes outside the complex to program much of the development of the thorax and abdomen of the fly. The emphasis in this paper will be on how the genes of the complex are themselves regulated, rather than on how they regulate other genes.
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References
Akam M., H. Moore, and A. Cox. 1984. Ultrabithorax mutations map to distant sites within the bithorax complex of Drosophila. Nature 309: 6
Arai K. and A. Kornberg. 1981. Unique primed start of phage φX174 DNA replication and mobility of the primosome in a direction opposite chain synthesis. Proc. Natl. Acad. Sci. 78: 69.
Beachy P. A., S. L. Helfand, and D. S. Hogness. 1985. Segmental distribution of bithorax complex proteins during Drosophila development. Nature 313: 545.
Bender W., M. Akam, F. Karch, P. A. Beachy, M. Peifer, P. Spierer, E. B. Lewis, and D. S. Hogness. 1983. Molecular genetics of the bithorax complex in Drosophila melanogaster. Science 221: 23.
Capdevila M. P. and M. Garcia-Bellido. 1981. Genes involved in the activation of the bithorax complex of Drosophila. Wilhelm Roux’s Arch. Dev. Biol. 190: 339.
Celniker S. E. and E. B. Lewis. 1984. Transabdominal: A new dominant mutant in the bithorax gene complex (BX-C) of Drosophila melanogaster. Genetics 107: S17.
Denell R. E. and R. D. Frederick. 1983. Homoeosis in Drosophila: A description of the Polycomb lethal syndrome. Dev. Biol. 97: 34.
Duncan I. 1982. Localization of bithorax complex (BX-C) and Antennapedia complex (ANT-C) gene activities along the body axis of Drosophila. Genetics 100: S20.
Duncan I. and E. B. Lewis. 1981. Genetic control of body segment differentiation in Drosophila. Symp. Soc. Dev. Biol. 40: 3.
Dura J. M., H. W. Brock, and P. Santamaria. 1985. Polyhomeotic: A gene of Drosophila melanogaster required for correct expression of segmental identity. Mol. Gen. Genet. 198: 213.
Garcia-Bellido A. and M. P. Capdevila. 1978. The initiation and maintenance of gene activity in a developmental pathway of Drosophila. Symp. Soc. Dev. Biol. 36: 3.
Gausz J., H. Gyurkovics, and A. Parduczy. 1981. A new homeotic mutation, SGA62, in Drosophila melanogaster. Acta Biol. Acad. Sci. Hung. 32: 219.
Ingham P.W. 1981. trithorax: A new homeotic mutation of Drosophila melanogaster. II. The role of trx+ after embryogenesis. Wilhelm Roux’s Arch. Dev. Biol. 190: 365.
Ingham P.W. 1983. Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes. Nature 306: 591.
Ingham P.W. 1984. A gene that regulates the bithorax complex differentially in larval and adult cells of Drosophila. Cell 37: 815.
Ingham P. W. and J. R. S. Whittle. 1980. trithorax: A new homeotic mutation of Drosophila melanogaster causing transformations of abdominal and thoracic imaginal segments. Mol. Gen. Genet. 179: 607.
Karch, F., B. Weiffenbach, M. Peifer, W. Bender, I. Duncan, S. Celniker, M. Crosby, and E. B. Lewis. 1985. The abdominal region of the bithorax complex. Cell (in press).
Kerridge S. and G. Morata. 1982. Developmental effects of some newly induced Ultrabithorax alleles of Drosophila. J. Embryol. Exp. Morphol. 68: 211.
Lewis E. B. 1951. Pseudoallelism and gene evolution. Cold Spring Harbor Symp. Quant. Biol. 16: 159.
Lewis E. B. 1954. The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. Am. Nat. 88: 225.
Lewis E. B. 1955. Some aspects of position pseudoallelism. Am. Nat. 89: 73.
Lewis E. B. 1963. Genes and developmental pathways. Am. Zool. 3: 33.
Lewis E. B. 1964. Genetic control and regulation of developmental pathways. In Role of chromosomes in development (ed. M. Locke), p. 231. Academic Press New York.
Lewis E. B. 1968. Genetic control of developmental pathways in Drosophila melanogaster. Proc. Int. Congr. Genet. 2: 96.
Lewis E. B. 1978. A gene complex controlling segmentation in Drosophila. Nature 276: 565.
Lewis E. B. 1981. Developmental genetics of the bithorax complex in Drosophila. ICN-UCLA Symp. Mol. Cell. Biol. 23: 189.
Lewis E. B. 1982. Control of body segment differentiation in Drosophila by the bithorax gene complex. In Proceedings of the 9th Congress of the International Society of Developmental Biologists (ed. M. M. Burger), p. 269. A. R. Liss New York.
Lohs-Schardin M., C. Cremer, and C. Nusslein-Volhard. 1979. A fate map for the larval epidermus of Drosophila melanogaster: Localized cuticle defects following irradiation of the blastoderm with an ultraviolet laser microbeam. Dev. Biol. 73: 239.
Mcginnis W., M. S. Levine E. Hafen A. Kuroiwa, and W. Gehring. 1984. A conserved DNA sequence in homeotic genes of the Drosophila Antennapedia and bithorax complexes. Nature 308: 428.
Peattie D. A. and D. S. Hogness. 1984. Molecular analysis of the bxd locus within the bithorax complex of Drosophila. Genetics 107: S81.
Sanchez-Herrero E., I. Vernos R. Marco, and G. Morata. 1985. Genetic organization of Drosophila bithorax complex. Nature 313: 108.
Scott M. P. and A. J. Weiner, 1984. Structural relationships among genes that control development: Sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc. Natl. Acad. Sci. 81: 4115.
Stern C. and E. Hadorn. 1939. The relation between the color of testes and vasa efferentia in Drosophila. Genetics 24: 162.
Struhl G. 1981. A gene product required for the correct initiation of segmental determination in Drosophila. Nature 293: 36.
Struhl G. 1984. Splitting the bithorax complex of Drosophila. Nature 308: 454.
White R. A. H. and M. Wilcox. 1984. Protein products of the bithorax complex in Drosophila. Cell 39: 163.
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Lewis, E.B. (1985). Regulation of the Genes of the Bithorax Complex in Drosophila . In: Lipshitz, H.D. (eds) Genes, Development and Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8981-9_16
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DOI: https://doi.org/10.1007/978-1-4419-8981-9_16
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