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Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity

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ADP-Ribosylation Reactions

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Abstract

Poly(ADP-ribosyl)ation is a posttranslational protein modification catalyzed by poly(ADP-ribose) polymerase (PARP1), a highly conserved nuclear enzyme which uses nicotinamide-adenine dinucleotide (NAD) as substrate (for review, see Althaus &Richter, 1987). Poly(ADP-ribosyl)ation is thought to play a role in DNA repair and other cellular responses to DNA damage, such as cell cycle perturbations, clastogenesis, mutagenesis, malignant transformation, but also in DNA replication, integration of transfected foreign DNA into the cell genome, signal transduction, differentiation, and aging.

ArticleNote

1The abbreviations used are: 3AB, 3-aminobenzamide; AF, amplification factor; DHFR, dihydrofolate reductase; EF, enhancement factor; MNNG, Nmethyl-N’-nitro-N-nitrosoguanidine; MTX, methotrexate; PARP, poly(ADPribose) polymerase; PE, plating efficiency; SV40, Simian virus 40

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Authors
  1. Alexander Bürkle
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  2. Karlheinz Grube
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  3. Jan-Heiner Küpper
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Editor information

Editors and Affiliations

  1. Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Quebec, G1V 4G2, Canada

    Guy G. Poirier

  2. Biochemistry Department Pavillon Vachon, Universite Laval, Quebec, G1K 7P4, Canada

    Pierre Moreau

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© 1992 Springer Science+Business Media New York

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Bürkle, A., Grube, K., Küpper, JH. (1992). Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_30

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  • DOI: https://doi.org/10.1007/978-1-4419-8718-1_30

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6456-9

  • Online ISBN: 978-1-4419-8718-1

  • eBook Packages: Springer Book Archive

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