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The Role of Histamine in Ocular Allergy

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Histamine in Inflammation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 709))

Abstract

Ocular allergy is a disorder affecting increasing numbers of individuals worldwide. Among the inflammatory mediators that contribute to ocular allergy, histamine is perhaps the best characterized. This monoamine is released by sensitized mast cells upon exposure to allergen and causes symptoms such as redness and tearing. Histamine may also recruit immune cells that can cause long-term damage to ocular surfaces. In this chapter we will discuss the known functions of histamine and histamine receptors in ocular allergy and will describe promising therapies targeting the histamine-signaling pathway.

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Author information

Authors and Affiliations

  1. Office of the Provost, Emory University, Administration Building, Suite 404, Atlanta, Georgia, 30322, USA

    Santa J. Ono

Authors
  1. Masaharu Ohbayashi
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  2. Bita Manzouri
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  3. Kei Morohoshi
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  4. Ken Fukuda
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  5. Santa J. Ono
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Corresponding author

Correspondence to Santa J. Ono .

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Editors and Affiliations

  1. Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, California, USA

    Robin L. Thurmond PhD

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© 2010 Landes Bioscience and Springer Science+Business Media, LLC

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Ohbayashi, M., Manzouri, B., Morohoshi, K., Fukuda, K., Ono, S.J. (2010). The Role of Histamine in Ocular Allergy. In: Thurmond, R.L. (eds) Histamine in Inflammation. Advances in Experimental Medicine and Biology, vol 709. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8056-4_5

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