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Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease

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Molecular Pathology of Hematolymphoid Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 4))

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Abstract

Evaluation for the presence of neoplastic cells or karyotypic abnormalities has traditionally been performed to monitor therapeutic response of hematolymphoid neoplasms. The application of multicolor flow cytometry and nucleic acid amplification techniques has extended evaluable markers and lowered limits of detection, thus leading to the term “minimal residual disease” (MRD). The ability to monitor MRD has, in turn, led to new concepts in the definition of disease “remission” and early relapse and opportunities for personalized therapy. This chapter focuses on the principles of the molecular assessment of MRD.

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  1. Molecular Diagnostics, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA

    Marie E. Beckner MD

  2. Division of Molecular Diagnostics, Department of Pathology and Human Genetics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Jeffrey A. Kant MD, PhD

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  1. Dept. Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, 27599-7525, USA

    Cherie H. Dunphy

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Beckner, M.E., Kant, J.A. (2010). Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease. In: Dunphy, C. (eds) Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology Library, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5698-9_10

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