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Vitamin D in Critical Illness

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Intensive Care Medicine

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Abstract

Vitamin D is well known for its regulatory effects on calcium and phosphate homeostasis and its role in the maintenance of bone integrity. Over the past decade, there have been data from biochemical and molecular genetic studies that point to vitamin D having a much wider role than just maintenance of calcium and phosphate metabolism. Vitamin D and its synthetic analogues have been shown to have anticancer properties as well as to modulate the immune system. Recently, vitamin D deficiency has been reported in critically ill patients [1, 2]. However, it is still unclear how this deficiency affects patient outcomes in intensive care. The focus of this chapter is to examine the role of vitamin D in the body, with discussion of its effects on mineral and bone metabolism as well as its pleiotropic effects and the role it may play in the pathophysiology of critical illness.

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Authors and Affiliations

  1. Department of Intensive Care, Princess Alexandra and Ipswich Hospitals, Brisbane, QLD, 4102, Australia

    A. Krishnan, J. Ochola & B. Venkatesh

Authors
  1. A. Krishnan
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  2. J. Ochola
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  3. B. Venkatesh
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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Krishnan, A., Ochola, J., Venkatesh, B. (2010). Vitamin D in Critical Illness. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5562-3_26

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  • DOI: https://doi.org/10.1007/978-1-4419-5562-3_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-5561-6

  • Online ISBN: 978-1-4419-5562-3

  • eBook Packages: MedicineMedicine (R0)

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