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Ovarian Tissue Cryopreservation

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Practical Manual of In Vitro Fertilization

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Abstract

There is a large need for fertility preservation options for cancer survivors, yet at this time, ovarian tissue cryopreservation for fertility preservation remains experimental. Ovarian cortex banking may be offered to patients undergoing gonadotoxic therapy under an approved experimental protocol when ovarian stimulation and in vitro fertilization are not options. Cryopreservation and reimplantation of whole ovaries are areas where more research needs to be performed before it can be offered, even experimentally, to patients desiring fertility preservation. Future work will focus on clarifying patient selection for ovarian tissue cryopreservation. In addition, technical methods of cryopreservation of ovarian tissue should be optimized to enhance follicular survival. Lastly, surgical techniques for revascularization of thawed whole ovaries need to be perfected. The current outlook is hopeful that in the near future, ovarian tissue cryopreservation will be a viable treatment option for fertility preservation.

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Author information

Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, CT, USA

    Jennifer L. Kulp MD & J. Ryan Martin MD

  2. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, Yale Fertility Center, New Haven, CT, USA

    Pasquale Patrizio MD, MBE, HCLD

Authors
  1. Jennifer L. Kulp MD
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  2. J. Ryan Martin MD
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  3. Pasquale Patrizio MD, MBE, HCLD
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Corresponding author

Correspondence to Pasquale Patrizio MD, MBE, HCLD .

Editor information

Editors and Affiliations

  1. , Scientific and Laboratory Director, Reproductive Biology Associates, Atlanta, 30342, Georgia, USA

    Zsolt Peter Nagy

  2. , Sr. Embryologist, Montreal Reproductive Centre, Montreal, H4A 3J3, Québec, Canada

    Alex C. Varghese

  3. Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Euclid Avenue 9500, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Kulp, J.L., Martin, J.R., Patrizio, P. (2012). Ovarian Tissue Cryopreservation. In: Nagy, Z., Varghese, A., Agarwal, A. (eds) Practical Manual of In Vitro Fertilization. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1780-5_61

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  • DOI: https://doi.org/10.1007/978-1-4419-1780-5_61

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