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MLH1

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Cancer Therapeutic Targets

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Abstract

MLH1 along with other mismatch repair (MMR) genes play a critical role in postreplicative MMR during DNA replication. Hereditary nonpolyposis colon cancer (HNPCC) is associated with mutations in MLH1 and other MMR genes. Mutations in MLH1 are associated with the microsatellite instability (MSI) seen in colon cancers.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, 593 Eddy St, 02903, Providence, RI, USA

    Timothy Kinsella & Kara Lynne Leonard

Authors
  1. Timothy Kinsella
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  2. Kara Lynne Leonard
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Corresponding author

Correspondence to Timothy Kinsella .

Editor information

Editors and Affiliations

  1. Division of Hematology & Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA

    John L. Marshall

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© 2017 Springer Science+Business Media New York

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Kinsella, T., Leonard, K.L. (2017). MLH1. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0717-2_8

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