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Encyclopedia of Signaling Molecules pp 574–586Cite as

Eps8 (Epidermal Growth Factor Receptor Pathway Substrate 8)

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Synonyms

Epidermal growth factor receptor kinase substrate 8; Epidermal growth factor receptor pathway substrate 8

Historical Background

Eps8 (EGFR pathway substrate #8) is an actin-binding and signaling molecule with a molecular weight of 97KDa encoded by a gene comprising 21 exons located on the human chromosome 12p12. It was originally identified through an expression cloning approach designed to isolate intracellular substrates for the tyrosine kinase of the Epidermal Growth Factor Receptor (EGFR) (Fazioli et al. 1993). Eps8 is efficiently phosphorylated on tyrosine residues by a variety of both receptor and non-receptor tyrosine kinases (Fazioli et al. 1993). Following stimulation with neurotrophic factor BDNF, which critically controls growth and differentiation processes in the brain during development, through the activation of Trk tyrosine kinase receptors, Eps8 can also be phosphorylated, in a MAPK-dependent manner, on serine and threonine residues. Notably, while the...

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Acknowledgment

This study was supported by the NIH Cell Migration Consortium grant U54 GM064346 from the National Institute of General Medical Sciences (NIGMS) to DH and NV; from the Associazione Italiana per la Ricerca sul Cancro (AIRC), the Italian Ministries of Education-University-Research (MIUR-PRIN) and of Health, AICR (International Association For Cancer Research – AICR), and from IFOM Foundation to GS; FM is supported by a fellowship from Fondazione Italiana Ricerca sul Cancro (FIRC).

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Authors and Affiliations

  1. IFOM, Via Adamello 16, 20139, Milan, Italy

    Dr. Francesca Milanesi & Dr. Giorgio Scita

  2. Bioinformatics and Systems Biology Program, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Dr. Niels Volkmann & Dr. Dorit Hanein

  3. Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, 20122, Milan, Italy

    Dr. Giorgio Scita

Authors
  1. Dr. Francesca Milanesi
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  2. Dr. Niels Volkmann
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  3. Dr. Giorgio Scita
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  4. Dr. Dorit Hanein
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Corresponding author

Correspondence to Giorgio Scita .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Milanesi, F., Volkmann, N., Scita, G., Hanein, D. (2012). Eps8 (Epidermal Growth Factor Receptor Pathway Substrate 8). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_165

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