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Imaging in CNS Disease States: PTSD

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Imaging in CNS Drug Discovery and Development

Abstract

Posttraumatic stress disorder (PTSD) is associated with changes in specific brain regions. These brain regions, which include the amygdala, hippocampus, and prefrontal cortex, are involved in memory as well as the stress response. Brain studies in patients with posttraumatic stress disorder (PTSD) have replicated findings in animal studies by finding alterations in these brain areas. Brain areas implicated in PTSD play an important role in the stress response as well as memory, highlighting the important interplay between memory and the traumatic stress response. Abnormalities in these brain areas are hypothesized to underlie symptoms of PTSD.

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  1. Emory University, 1256 Briarcliff Rd, Room 308e, Mailstop 1256/001/AT, Atlanta, GA, 30306, USA

    J. Douglas Bremner

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  1. Mill Street 115, Belmont, 02478, U.S.A.

    David Borsook

  2. Mill Street 115, Belmont, 02478, U.S.A.

    Lino R. Beccera

  3. Dept. Psychiatry, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom

    Edward Bullmore

  4. Sumneytown Pike , West Point, 19486, U.S.A.

    Richard J. Hargreaves

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Bremner, J.D. (2010). Imaging in CNS Disease States: PTSD. In: Borsook, D., Beccera, L., Bullmore, E., Hargreaves, R. (eds) Imaging in CNS Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0134-7_21

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