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Autoimmunity—Aging Mouse Model for Autoimmune Diseases

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Handbook on Immunosenescence

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Abstract

Recent evidences suggest that the apoptotic pathway plays a central role in tolerazing T-cells to tissue-specific self-antigen, and may drive the age-related autoimmune phenomenon. Primary Sjögren’s syndrome (SS) is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the exocrine glands, and systemic production of autoantibodies to the ribonucleoprotein (RNP) particles SS-A/Ro and SS-B/La. It can be considered that a defect in activation induced cell death (AICD) of effector T-cells may result in the progression of autoimmune exocrinopathy in SS. We found that aging-associated disturbances in T-cell homeostasis are accelerated in the animal model with SS, resulting in the development of extraglandular manifestation including autoimmune arthritis and interstitial pneumonia. We demonstrated that tissue-specific apoptosis may contribute to autoantigen cleavage, leading to the age-related acceleration of autoimmune exocrinopathy. The immune system undergoes profound changes with advancing age that are beginning to be understood and that need to be incorporated into the pathogenesis of SS. The studies reviewed the molecular mechanisms on aging-associated progression in animal model of autoimmune exocrinopathy.

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Author information

Authors and Affiliations

  1. Department of Oral Molecular Pathology Institute of Health Biosciences, The University of Tokushima Graduate School, 3 Kuramotocho, Tokushima, 770-8504, Japan

    Yoshio Hayashi & Naozumi Ishimaru

Authors
  1. Yoshio Hayashi
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  2. Naozumi Ishimaru
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Editor information

Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Hayashi, Y., Ishimaru, N. (2009). Autoimmunity—Aging Mouse Model for Autoimmune Diseases. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_52

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