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Role of Dendritic Cells in Aging

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Handbook on Immunosenescence

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Abstract

Immunesenescence is characterized by a decline in immune functions which is responsible for majority of morbidity and mortality associated with aging. The possible consequences of this progressive aging of the immune system are an increase in autoimmune phenomena, incidence of malignancies and predisposition to infections. Innate immune system is the primary defense against invading pathogens. Moreover, it also initiates and modulates the functions of adaptive immune system. This review focuses on the age-associated changes in the functions of dendritic cells, the major antigen presenting cells of the innate immune system.

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References

  1. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ Gurney AL (2003) Interleukin 23 promotes a distinct CD4 +T cell activation state characterized by the production of IL-17. J Biol Chem 278:1910–1914

    Article  PubMed  CAS  Google Scholar 

  2. Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J,Van Dyke T, Pulendran B (2003) Cutting edge: different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol 171:4984–4989

    PubMed  CAS  Google Scholar 

  3. Agrawal A, Kaushal P, Agrawal S, Gollapudi S, Gupta S (2007) Thimerosal affects human dendritic cell functions promoting a TH2 response. J Leukocyte Biology 81:474–483

    Article  CAS  Google Scholar 

  4. Agrawal A, Agrawal S, Cao JN, Su H, Osann K, Gupta S (2007) Altered innate immune functioning of dendritic cells in aging humans: Role of PI3Kinase signaling pathway. J Immunol 178:6912–6922

    PubMed  CAS  Google Scholar 

  5. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell. 124:783–801

    Article  PubMed  CAS  Google Scholar 

  6. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, et al (2000) Immunobiology of dendritic cells. Annu Rev Immunol 18:767–811

    Article  PubMed  CAS  Google Scholar 

  7. Bhushan M, Cumberbatch M, Dearman RJ, Andrew SM, Kimber I and Griffiths CE (2002) Tumor necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing. Br J Dermatol 146:32–40

    Article  PubMed  CAS  Google Scholar 

  8. Boehmer ED, Meehan MJ, Cutro BT, Kovacs EJ (2005) Aging negatively skews macrophage TLR2- and TLR4-mediated proinflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev 126:1305–1313

    Article  PubMed  CAS  Google Scholar 

  9. Bruunsgaard H, Pedersen M, Pedersen BK (2001) Aging and proinflammatory cytokines. Curr Opin Hematol 8:131–136

    Article  PubMed  CAS  Google Scholar 

  10. Caux C, et al (1994) Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells. Int Immunol. 8:1177–1185

    Article  Google Scholar 

  11. Choi KL, Sauder DN (1987) Epidermal Langerhans cell density and contact sensitivity in young and aged BALB/c mice. Mech Age Dev 39:69–79

    Article  CAS  Google Scholar 

  12. Cohen HJ, Pieper CF, Harris T, Rao KM, Currie MS (1997) The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol A Biol Sci Med Sci 52: M201–M208

    PubMed  CAS  Google Scholar 

  13. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421:744–748

    Article  PubMed  CAS  Google Scholar 

  14. Cumberbatch M, Dearman RJ, Kimber I (2000) Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin-1beta. Immunology 105:466–477

    Article  Google Scholar 

  15. Della Bella S, Bierti L, Presicce P, Arienti R, Valenti M, Saresella M, Vergani C, Villa ML (2007) Peripheral blood dendritic cells and monocytes are differently regulated in the elderly. 2007. Clin Immunol. 122:220–228

    Article  PubMed  CAS  Google Scholar 

  16. Dobbs RJ, Charlett A, Purkiss AG, Dobbs SM, Weller C, Peterson, DW (1999) Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. Acta Neurol Scand 100:34–41

    Article  PubMed  CAS  Google Scholar 

  17. Donnini A, Argentati K, Mancini R, et al (2002) Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old age. Exp Gerontol 37:1097–1112

    Article  PubMed  CAS  Google Scholar 

  18. Dunn-Walters D K, Banerjee M, Mehr R (2003) Effects of age on antibody affinity maturation. Biochem Soc Trans 31:447–448

    Article  PubMed  CAS  Google Scholar 

  19. Fagiola U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E, Monti D, Franceschi C, Paganelli R (1993) Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 23:2375–2378

    Article  Google Scholar 

  20. Forster R, Schubel A, Brietfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M (1999) CCR-7 coordinates primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23–33

    Article  PubMed  CAS  Google Scholar 

  21. Grewe M (2001) Chronological ageing and photoageing of dendritic cells. Clin Exp Dermatol 26:608–612

    Article  PubMed  CAS  Google Scholar 

  22. Grolleau-Julius A, Garg MR, Mo R, Stoolman LL, Yung RL (2006) Effect of aging on bone marrow-derived murine CD11c+CD4-CD8alpha—dendritic cell function. J Gerontol A Biol Sci Med Sci 61:1039–1047

    PubMed  Google Scholar 

  23. Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S (2004) Characterization of naive, memory and effector CD8+ T cells: effect of age. Exp Gerontol 39:545–550

    Article  PubMed  CAS  Google Scholar 

  24. Haruna H, Inaba M, Inaba K, Taketani S, Sugiura K, Fukuba Y, Doi H, Toki J, Tokunaga R, Ikehara S (1995) Abnormalities of B cells and dendritic cells in SAMP1 mice. Eur J Immunol 25:1319–1325

    Article  PubMed  CAS  Google Scholar 

  25. Hawiger D, Inaba K, Dorsett Y, Guo M, Mahnke K, Rivera M, Ravetch JV, Steinman RM, Nussenzweig MC (2001) Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 194:769–779

    Article  PubMed  CAS  Google Scholar 

  26. Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL (2003) CD4 T cell memory derived from young naïve cells functions well into old age, while memory generated from Elderly naïve cells functions poorly. Proc Natl Acad Sci USA 100:15053–15058

    Article  PubMed  CAS  Google Scholar 

  27. Hirokawa K (1999) Age-related changes of signal transduction in T cells. Exp Gerontol 34:7–18

    Article  PubMed  CAS  Google Scholar 

  28. Iwasaki A, Medzhitov R (2004) Toll-like receptor control of the adaptive immune responses. Nat Immunol 5:987–995

    Article  PubMed  CAS  Google Scholar 

  29. Jarrossay D, Napolitani G, Colonna M, Sallusto F, Lanzavecchia A (2001) Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells Eur J Immunol 31:3388–3393

    Article  PubMed  CAS  Google Scholar 

  30. Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, Knop J, Enk AH (1997) Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 27(12):3135–3142

    Article  PubMed  CAS  Google Scholar 

  31. Katz JM, Plowden J, Renshaw-Hoelscher M, Lu X, Tumpey TM, Sambhara S (2004) Immunity to influenza: the challenges of protecting an aging population. Immunol Res 29:113–124

    Article  PubMed  CAS  Google Scholar 

  32. Kellermann SA, Hudak S, Oldham ER, Liu YJ, McEvoy LM (1999) TheCCchemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein 3 are potent chemoattractants for in vitro- and in vivo-derived dendritic cells. J Immunol 162:3859–3864

    PubMed  CAS  Google Scholar 

  33. Komatsubara S, Cinader B, Muramatsu S (1986) Functional competence of dendritic cells of ageing C57BL/6 mice. Scand J Immunol 24:517–525

    Article  PubMed  CAS  Google Scholar 

  34. Langrish CL, Chen Y, Blumenschein WM, Mattson JD, Chen T, Smith K, Basham B, McClanahan T, Kastelein RA, Cua DJ (2005) IL-23-drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201:233–240

    Article  PubMed  CAS  Google Scholar 

  35. Linton PJ, Haynes L, Klinman NR, Swain SL (1996) Antigen-independent changes in naïve CD4 T cells with aging. J Exp Med 184:1891–1900

    Article  PubMed  CAS  Google Scholar 

  36. Linton PJ, Dorshkind, K (2004) Age-related changes in lymphocyte development and function. Nat Immunol 5:133–139

    Article  PubMed  CAS  Google Scholar 

  37. Linton PJ, Li SP, Zhang Y, Bautista B, Huynh Q, Trinh T (2005) Intrinsic versus environmental influences on T-cell responses in aging. Immunol Rev 205:207–219

    Article  PubMed  CAS  Google Scholar 

  38. Liu YJ (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 23:275–306

    Article  PubMed  CAS  Google Scholar 

  39. Lung TL, Saurwein-Teissl M, Parson W, Schonitzer D, Grubeck-Loebenstein B (2000) Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells. Vaccine 18:1606–1612

    Article  PubMed  CAS  Google Scholar 

  40. McGeer PL, McGeer, EG (2004) Inflammation and the degenerative diseases of aging. Ann N Y Acad Sci (2004) 1035:104–116

    Article  CAS  Google Scholar 

  41. McBean AM, Hebert PL (2004) New estimates of influenza-related pneumonia and influenza hospitalizations among the elderly. Int J Infect Dis 8:227–235

    Article  PubMed  Google Scholar 

  42. Miller RA, Garcia G, Kirk CJ, Witkowski, JM (1997) Early activation defects in T lymphocytes from Elderly mice. Immunol Rev 160:79–90

    Article  PubMed  CAS  Google Scholar 

  43. Paolisso G, Rizzo MR, Mazziotti G, Tagliamonte MR, Gambardella A, Rotondi M (1998) Advancing age and insulin resistance: role of plasma tumor necrosis factor-alpha. Am J Physiol 275:E294–E299

    PubMed  CAS  Google Scholar 

  44. Pawalec G, Remarque E, Barnett Y, Solana R (1998) T cells and aging. Front Biosci 3: D59–D99

    Google Scholar 

  45. Piemonti L, Monti P, Allavena P, Sironi M, Soldini L, Leone BE, Socci C (1999) Glucocorticoids affect human dendritic cell differentiation and maturation. J Immunol 162(11):6473–6481

    PubMed  CAS  Google Scholar 

  46. Pietschmann P, Hahn P, Kudlacek S, Thomas R, Peterlik M (20 Surface markers and transendothelial migration of dendritic cells from elderly subjects. Exp Gerontol 35:213–222

    Google Scholar 

  47. Rees D, Miles EA, Banerjee T (2006) Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am J Clin Nutr 83:331–342

    PubMed  CAS  Google Scholar 

  48. Renshaw M, Rockwell J, Engleman C, Gewirtz A, Katz J, Sambhara S (2002) Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol 169:4697–4701

    PubMed  CAS  Google Scholar 

  49. Rink I, Kirchner H (1998) Altered cytokine production in the elderly. Mech Ageing Dev 102:199–209

    Article  PubMed  CAS  Google Scholar 

  50. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov, R (2001) Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2:947–650

    Article  PubMed  CAS  Google Scholar 

  51. Seeds RE, Gordon S, Miller JL (2006) Receptors and ligands involved in viral induction of type I interferon production by plasmacytoid dendritic cells. Immunobiology 211(6–8):525–535

    Article  PubMed  CAS  Google Scholar 

  52. Sharma S, Dominguez AL, Lustgarten J (2006) Aging affect the anti-tumor potential of dendritic cell vaccination, but it can be overcome by co-stimulation with anti-OX40 or anti-4-1BB, Exp Gerontol 41:78–84

    Article  PubMed  CAS  Google Scholar 

  53. Shodell M, Siegal FP (2002) Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing. Scand J Immunol 56(5):518–521

    Article  PubMed  CAS  Google Scholar 

  54. Solana R, Pawelec G, Tarazona R (2006) Aging and innate immunity. Immunity 24:491–494

    Article  PubMed  CAS  Google Scholar 

  55. Sprecher E, Becker Y, Kraal G, Hall E, Harrison D, Shultz LD (1990) Effect of aging on epidermal dendritic cell populations in C57BL/6J mice. J Invest Dermatol 94:247–253

    Article  PubMed  CAS  Google Scholar 

  56. Steger MM, Maczek C, Grubeck-Loebenstein B (1996) Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals. Clin Exp Immunol 105:544–550

    Article  PubMed  CAS  Google Scholar 

  57. Steinman RM, Turley S, Mellman I, Inaba K (2000) The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 191:411–416

    Article  PubMed  CAS  Google Scholar 

  58. Steinman RM, Hawiger D, Nussenzweig MC (2003) Tolerogenic dendritic cells [review]. Annu Rev Immunol 21:685–711

    Article  PubMed  CAS  Google Scholar 

  59. Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR (2006) Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell 5:473–486

    Article  PubMed  CAS  Google Scholar 

  60. Utsuyama M, Hirokawa K, Kurashima C, Fukayama M, Inamatsu T, Suzuki K, Hashimoto W, Sato K (1992) Differential age-change in the numbers of CD4+CD45RA+ and CD4+CD29+T cell subsets in human peripheral blood. Mech Ageing Dev 63:57–68

    Article  PubMed  CAS  Google Scholar 

  61. Uyemura K, Castle SC, Makinodan T (2002) The frail elderly: role of dendritic cells in the susceptibility of infection. Mech Ageing Dev 123(8):955–962

    Article  PubMed  CAS  Google Scholar 

  62. Van Duin D, Mohanty S, Thomas V, Ginter S, Montgomery RR, Fikrig E, Allore HG, Medzhitov R, Shaw AC (2007) Age-associated defect in human TLR-1/2 function. J Immunol 178:970–975

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Sciences I, C-240, Division of Basic and Clinical Immunology, University of California, 92697, Irvine, USA

    Anshu Agrawal, Sudhanshu Agrawal & Sudhir Gupta

Authors
  1. Anshu Agrawal
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  2. Sudhanshu Agrawal
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  3. Sudhir Gupta
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Editor information

Editors and Affiliations

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036 Rue Belvedere, J1H 4C4, Sherbrooke, Quebec, Canada

    Tamas Fulop

  2. Department of Experimental Pathalogy, CIG Interdepartmental Center “L. Galvani” University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, 4-6-22 Kohinato, Bunkyo-ku, Tokyo, 112-0006, Japan

    Katsuiku Hirokawa

  4. ZMF - Zentrum Med. Forschung Abt. Transplant./ Immunologie, University of Tübingen, Waldhörnlestr. 22, 72072, Tübingen, Germany

    Graham Pawelec

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Agrawal, A., Agrawal, S., Gupta, S. (2009). Role of Dendritic Cells in Aging. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook on Immunosenescence. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9063-9_25

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