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Targeting the toxoplasma gondii apicoplast for chemotherapy

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Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia

Part of the book series: World Class Parasites ((WCPA,volume 9))

Abstract

The apicoplast represents a potential drug target to combat Toxoplasma gondii infection, as it is essential to the parasite and absent from host cells. Functions of the apicoplast include fatty acids synthesis, protein synthesis, DNA replication, electron transport, and heme biosynthesis. Each pathway and its potential for new chemotherapeutic leads will be discussed.

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Authors and Affiliations

  1. Division of Geographic Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA

    Sunny C. Yung & Naomi Lang-Unnasch

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  1. Sunny C. Yung
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  2. Naomi Lang-Unnasch
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Editors and Affiliations

  1. Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, USA

    David S. Lindsay

  2. Albert Einstein College of Medicine, Bronx, New York, USA

    Louis M. Weiss

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© 2004 Kluwer Academic Publishers

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Yung, S.C., Lang-Unnasch, N. (2004). Targeting the toxoplasma gondii apicoplast for chemotherapy. In: Lindsay, D.S., Weiss, L.M. (eds) Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia. World Class Parasites, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4020-7846-0_3

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  • DOI: https://doi.org/10.1007/978-1-4020-7846-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7814-9

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