Bioassays in Genetic Toxicology

Bioassays have been designed to assess mutagenic (and indirectly carcinogenic) properties of factors that human, animal, plant and microbial populations may be exposed to. Their range varies from testing chromosome breakage and point mutations in a wide variety of organisms using different endpoints. All the different procedures cannot be discussed or even enumerated here but the major types of tests include: (i) excision repair, (ii) reversion studies in Salmonella and E. coli, (iii) sister chromatid exchange, (iv) mitotic recombination, (v) host‐mediated assays, (vi) specific locus mutation assays, (vii) micronuclei formation, (viii) chromosome breakage, (ix) sex‐linked lethal assays, (x) unscheduled DNA synthesis, (xi) sperm morphology studies, (xii) cell transformation assays, (xiii) dominant mutation,(xiv) somatic mutation detection, (xv) Arabidopsis mutagen assays, (xvi) human mutagenic assays, (xvii) mitotic recombination as a bioassay in genetic toxicology, (xviii) Tradescantia...