Abstract
Hematopoietic stem cell replacement therapy is an area of research lacking an optimal culture system that allows for the ex vivo expansion of CD34+ cells for transplant. The necessity for expansion is due to the lack of sufficient material from umbilical cord blood (UCB), the preferred source of CD34+ cells. The final composition of the expanded cells is also very important to a successful transplant. The material must contain both early and late progenitor cells to ensure the long-term engraftment that is required in patients with genetic disorders and those that have gone through high dose chemotherapy.
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Leugers, S.L., Allison, D.W., Liang, Y., Swiderski, C., Zant, G.V., Donahue, L.M. (2007). EX VIVO Expansion of CD34+ Cells in Stemline™ II Hematopoietic Stem Cell Expansion Medium Generates a Large Population of Functional Early and Late Progenitor Cells. In: Smith, R. (eds) Cell Technology for Cell Products., vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-5476-1_55
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DOI: https://doi.org/10.1007/978-1-4020-5476-1_55
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-5475-4
Online ISBN: 978-1-4020-5476-1
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