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Acid-base in dialysis

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

The correction of uremic metabolic acidosis has always represented one of fundamental aims of renal replacement therapies. Since the earliest experiences (1, 2) bicarbonate has been enclosed in the dialysis fluid in order to provide a source of base for patients without functioning kidneys. Poor bicarbonate solubility when mixed with divalent cations (calcium and magnesium) and easy bacterial contamination of dialysis fluid suggested a change in the buffer species and acetate was used instead of bicarbonate both in hemodialysis and peritoneal dialysis (3, 4). Acetate-containing solutions were easily prepared, chemically stable and microbiologically safe, thus becoming the first choice substance for acid-base derangement correction.

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Authors
  1. Mariano Feriani
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  2. Aldo Fabris
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  3. Giuseppe La Greca
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Editor information

Editors and Affiliations

  1. Division of Nephrology, Department of Medicine III, University of Vienna, Währinger Gurtel 18-20, A-1090, Vienna, Austria

    Walter H. Hörl

  2. Division of Nephrology, Centre for Internal Medicine and Dermatology, Medizinische Hochschule, Hannover, Germany

    Karl M. Koch

  3. Optimal Dialysis Research Unit, London Health Sciences Centre and The University of Western Ontario, London, Ontario, Canada

    Robert M. Lindsay

  4. Department of Nephrology, St. Bortolo Hospital, Viale Rodolfi, I-36100, Vicenza, Italy

    Claudio Ronco

  5. RenalTech International, LLC, 320 East 65th St, #116, New York, NY, 10021, USA

    James F. Winchester

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© 2004 Springer Science+Business Media Dordrecht

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Feriani, M., Fabris, A., Greca, G.L. (2004). Acid-base in dialysis. In: Hörl, W.H., Koch, K.M., Lindsay, R.M., Ronco, C., Winchester, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2275-3_33

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  • DOI: https://doi.org/10.1007/978-1-4020-2275-3_33

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-7012-1

  • Online ISBN: 978-1-4020-2275-3

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