Abstract
The role of gamma aminobutyric acid (GABA) in synaptic transmission in the central nervous system (CNS) is more firmly established than for any other transmitter. In addition, virtually every neurone receives a strong GABAergic input. It has long been known that the ionic mechanism involved in the inhibitory action of GABA involves an increase in membrane conductance to chloride ions. This action is blocked by a number of relatively selective antagonists, such as bicuculline. A number of recent studies have provided new insight into the action of GABA. First, the introduction of two new biophysical techniques, fluctuation analysis (Barker, et al., 1982) and single-channel recording (Hamill, et al., 1983) have considerably advanced our understanding of the properties of GABA-activated chloride channels. Secondly, GABA may have actions which do not involve chloride ions and are resistant to the action of known GABA antagonists.
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References
ALGER, B.E. (1984). Hippocampus: electrophysiological studies of epithelium activity in vitro. In Brain Slices. Dingledine, R. (ed.) pp. 155–193. New York: Plenum Press.
ALGER, B.E. & NICOLL, R.A. (1980). Epileptiform burst afterhyperpolarization: calcium-dependent potassium potential in hippocampal CAl pyramidal cells. Science, 210, 1122–1124.
ALGER, B.E. & NICOLL, R.A. (1982a). Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro. J. Physiol., 328, 195–223.
ALGER, B.E. & NICOLL, R.A. (1982b). Pharmacological evidence for two kinds of GABA receptor on rat hippocampal pyramidal cells studied in vitro. J. Physiol., 328, 125–141.
ALLAN, R.D., EVANS, R.H. & JOHNSTON, G.A.R. (1980). γ-Aminobutyric acid agonists: An in vitro comparison between depression of spinal synaptic activity and depolarization of spinal root fibres in the rat. Br. J. Pharmac., 70, 609–615.
ANDERSEN, P., DINGLEDINE, R., GJERSTAD, L., LANGMOEN, I.A. & MOSFELDT-LAURSEN, A. (1980). Two different responses of hippocampal pyramidal cells to application of gamma-aminobutyric acid. J. Physiol., 305, 279–296.
ANDERSEN, P., ECCLES, J.C. & LØYNING, Y. (1964). Location of post-synaptic inhibitory synapses on hippocampal pyramids. J. Neurophysiol., 27, 592–607.
BARKER, J.L., McBURNEY, R.N. & MacDONALD, J.R. (1982). Fluctuation analysis of neutral amino acid responses in cultured mouse spinal neurones. J. Physiol., 322, 365–388.
BLAXTER, T.J. & COTTRELL, G.A. (1982). Responses of rat hippocampal pyramidal cells to GABA and ethylene diamine. J. Physiol., 330, 46P.
BORMANN, J., SAKMANN, B. & SEIFERT, W. (1983). Isolation of GABA-activated single-channel Cl− currents in the soma membrane of rat hippocampal neurones. J. Physiol., 341, 9P.
BOWERY, N.G. (1982). Baclofen: 10 years on. Trends in Pharmac. Sci., 3, 400–403.
CONNORS, B.W., GUTNICK, M.J. & PRINCE, D.A. (1982). Electrophysiological properties of neocortical neurons in vitro. J. Neurophysiol., 48, 1302–1320.
CONSTANTI, A., CONNOR, J.D., GALVAN, M. & NISTRI, A. (1980). Intra-cellularly-recorded effects of glutamate and aspartate on neurones in the guinea-pig olfactory cortex slice. Brain Res., 195, 403–420.
FUGITA, Y. (1979). Evidence for the existence of inhibitory post-synaptic potentials in dendrites and their functional significance in hippocampal pyramidal cells of adult rabbits. Brain Res., 175, 59–69.
HAMILL, O.P., BORMANN, J. & SAKMANN, B. (1983). Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA. Nature, 305, 805–808.
HOTSON, J.R. & PRINCE, D.A. (1980). A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurones. J. Neurophysiol., 43, 409–419.
JAHNSEN, H. & MOSFELDT LAURSEN, A.M. (1981). The effects of a benzodiazepine on the hyperpolarizing and depolarizing responses of hippocampal cells to GABA. Brain Res., 207, 214–217.
JAHR, C.E. & NICOLL, R.A. (1982). An intracellular analysis of dendrodendritic inhibition in the turtle in vitro olfactory bulb. J. Physiol., 326, 213–234.
KANDEL, E.R., SPENCER, S.A. & BRINLEY, F.J. (1961). Electrophysiology of hippocampal neurons. I. Sequential invasion and synaptic organization. J. Neurophysiol., 24, 225–242.
LANCASTER, B. & WHEAL, H.V. (1983). Ca2+ dependence of afterhyperpolarizations (AHPs) in CA1 pyramidal cells of the rat. J. Physiol., 334, 118P.
MORI, K., NOWYCKY, M.C. & SHEPHERD, G.M. (1981). Analysis of synaptic potentials in mitral cells in the isolated turtle olfactory bulb. J. Physiol., 314, 295–309.
NEWBERRY, N.R. & NICOLL, R.A. (1984a). A bicucullineresistant inhibitory postsynaptic potential in rat hippocampal pyramidal cells in vitro. J. Physiol., 348, 239, 254.
NEWBERRY, N.R. & NICOLL, R.A. (1984b). Baclofen directly hyperpolarizes hippocampal pyramidal cells. Nature, 308, 450–452.
NEWBERRY, N.R. & NICOLL, R.A. (1984c). Similarities between the actions of baclofen and the slow i.p.s.p. transmitter in rat hippocampal pyramidal cells in vitro. J. Physiol (in press).
NICOLL, R.A. & ALGER, B.E. (1981). Synaptic excitation may activate a calcium-dependent potassium conductance in hippocampal pyramidal cells. Science, 212, 957–959.
SATOU, M., MORI, K., TAZAWA, Y. & TAKAGI, S. (1982). Two types of postsynaptic inhibition in pyriform cortex of the rabbit: fast and slow inhibitory postsynaptic potentials. J. Neurophysiol., 48, 1142–1156.
SOMOGYI, P., SMITH, A.D., NUNZI, M.G., GORIO, A., TAKAGI, H. & WU, J.Y. (1983). Glutamate decarboxylase immuno-reactivity in the hippocampus of the cat: distribution of immunoreactive synaptic terminals with special reference to the axon initial segment of pyramidal neurons. J. Neurosci., 3, 1450–1468.
STORM-MATHISEN, J. (1977). Localization of transmitter candidates in the brain: the hippocampal formation as a model. Prog. Neurobiol., 8, 119–181.
THALMANN, R.H. (1984). Reversal properties of an EGTA-resistant late hyperpolarization that follow synaptic stimulus of hippocampal neurones. Neurosci. Lea., 46, 103–105.
THALMANN, R.H. & AYALA. (1982). A late increase in potassium conductance follows synaptic stimulation of granule neurons of the dentate gyrus. Neurosci. Lett., 29, 243–248.
THALMANN, R.H., PECK, E.J. & AYALA, G.F. (1981). Biphasic response of hippocampal pyramidal neurons to GABA. Neurosci. Lett., 21, 319–324.
WONG, R.K.S & WATKINS, K.J. (1982). Cellular factors influencing GABA response in hippocampal pyramidal cells. J. Neurophysiol., 48, 938–951.
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© 1984 Macmillan Publishers Limited
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Nicoll, R.A., Newberry, N.R. (1984). Electrophysiology of GABA receptors in the vertebrate central nervous system. In: Paton, W., Mitchell, J., Turner, P., Padgham, C., Ashcroft, E. (eds) IUPHAR 9th International Congress of Pharmacology London 1984. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-17615-1_23
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DOI: https://doi.org/10.1007/978-1-349-17615-1_23
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