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Therapy of Tropical Diseases — Filariasis

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Clinical Pharmacology & Therapeutics

Abstract

The major human filarial parasites include Wuchereria bancrofti, Brugia malayi and B. timori responsible for lymphatic filariasis, Loa loa which causes loaiasis and Onchocerca volvulus which causes onchocerciasis. In addition, Dipetalonema perstans, D. streptocerca and Manzonella ozzardi infect man but are of doubtful pathogenicity. The adults of these parasites (macrofilariae) live for many years and produce larvae (microfilariae). In lymphatic filariasis and loaiasis the pathology is caused by the adult worms while in onchocerciasis, the microfilariae are responsible. These parasites affect millions of people in tropical and subtropical areas and produce chronic illness and disability. The treatment of filariasis has recently been reviewed by Hawking (1979). This paper will deal mainly with onchocerciasis, outline the problems posed by this disease and summarize recent work done in the field of human onchocerciasis chemotherapy.

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References

  • Abaru, D. E. & McMahon, J. E. (1978). Metrifonate in onchocerciasis and lymphatic filariasis. Tropenmed. Parasitol., 29, 175–177.

    CAS  PubMed  Google Scholar 

  • Anderson, J. & Fuglsang, H., (1973). Topical diethylcarbamazine in ocular onchocerciasis. Trans. Roy. Soc. Trop. Med. Hygiene, 67, 710–717.

    Article  CAS  Google Scholar 

  • Anderson, J., Fuglsang, H. & Marshall, T. F. de C. (1976). Effects of diethylcarbamazine on ocular onchocerciasis. Tropenmed. Parasitol., 27, 263–278.

    CAS  PubMed  Google Scholar 

  • Awadzi, K. (1980). The chemotherapy of onchocerciasis II: Quantitation of the clinical reaction to microfilaricides. Ann. Trop. Med. Parasitol., 74, 189–197.

    CAS  PubMed  Google Scholar 

  • Awadzi, K. & Gilles, H. M. (1980a). The chemotherapy of onchocerciasis III: A comparative study of diethylcarbamazine and metrifonate. Ann. Trop. Med. Parasitol., 74, 199–210.

    CAS  PubMed  Google Scholar 

  • Awadzi, K. & Gilles, H. M. (1980b). The chemotherapy of onchocerciasis IV: Further trials with metrifonate. Ann. Trop. Med. Parasitol., 74, 353–362.

    Google Scholar 

  • Awadzi, K., Haddock, D. R. W. & Gilles, H. M. (1980a). The chemotherapy of onchocerciasis I: Initial open evaluation of metrifonate. Ann. Trop. Med. Parasitol., 74, 53–61.

    CAS  PubMed  Google Scholar 

  • Awadzi, K., Roulet, H. & Bell, D. R. (1980b). A standard method for the determination of microfilarial densities in skin snips. Ann. Trop. Med. Parasistol., 74, 363–366.

    CAS  Google Scholar 

  • Ben-Sira, I., Aviel, E., Lazar, M., Lieberman, T. W. & Leopold, I. H. (1970). Tropical hetrazan in the treatment of ocular onchocerciasis. Am. J. Ophthalmol, 70, 741–743.

    Article  CAS  PubMed  Google Scholar 

  • Bryceson, A. D. M. (1976). What happens when microfilariae die? Trans. Rov. Soc. Trop. Med. Hygiene, 70, 397–399.

    Article  CAS  Google Scholar 

  • Bryceson, A. D. M., Warrell D. A. & Pope, H. M. (1977). Dangerous reactions to treatment of onchocerciasis with diethylcarbamazine. Brit. med. J., 1, 742–744.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Duke, B. O. L. (1971). Onchocerciasis. In Management and Treatment of Tropical Diseases pp. 292–300. Oxford and Edinburgh: Blackwell Scientific Publications.

    Google Scholar 

  • Duke, B. O. L. (1972). Effect of trichlorophon against the West African forest strain of O. volvulus. Ann. Trop. Med. Parasitol., 66, 163–164.

    CAS  PubMed  Google Scholar 

  • Duke, B. O. L. (1974a). Further trials with trichlorophon (metrifonate) against the West African forest strain of O. volvulus. Ann. Trop. Med. Parasitol., 68, 241–242.

    CAS  PubMed  Google Scholar 

  • Duke, B. O. L. (1974b). Mebendazole ineffective against O. volvulus. Trans. Roy. Soc. Trop. Med. Hygiene, 68, 172.

    Article  CAS  Google Scholar 

  • Duke, B. O. L. & Anderson, J. (1972). Onchocerciasis and its treatment. Trop. Doctor, 2, 107–114.

    Google Scholar 

  • Duke, B. O. L. & Anderson, J. (1975). Onchocerciasis. Trop. Doctor, 5, 141–142.

    Google Scholar 

  • Foster, R., Pringle, G., King, D. F. & Paris, J. (1969). The therapeutic activity of some nitrofurans in experimental filariasis and trypanosomiasis. Ann. Trop. Med. Parasitol., 63, 95–107.

    CAS  PubMed  Google Scholar 

  • Fuglsang, H. & Anderson, J. (1974). Collapse during treatment of onchocerciasis with diethylcarbamazine. Trans. Roy. Soc. Trop. Med. Hygiene, 68, 72–73.

    Article  CAS  Google Scholar 

  • Fuglsang, H. & Anderson, J. (1977). Effects of a single dose of metrifonate on the forest strain of Onchocerca volvulus in the Cameroon. Tropenmed. Parasitol., 28, 439–446.

    CAS  PubMed  Google Scholar 

  • Fuglsang, H. & Anderson, J. (1978a). Further studies on the treatment of onchocerciasis with metrifonate. Tropenmed. Parasitol., 29, 168–174.

    CAS  PubMed  Google Scholar 

  • Fuglsang, H. & Anderson, J. (1978b). A preliminary trial of nifurtimox in the treatment of onchocerciasis. Tropenmed. Parastiol., 29, 355–358.

    Google Scholar 

  • Hawking, F. (1979). Diethylcarbamazine and newer compounds for the treatment of filariasis. Adv. Pharmacol Chemother., 16, 129–194.

    Article  CAS  PubMed  Google Scholar 

  • Henson, P. M, MacKenzie, C. D. & Spector, W. G. (1979). Inflammatory reactions in onchocerciasis: a report on current knowledge and recommendations for further study. Bull WHO., 57, 667–682.

    PubMed Central  CAS  PubMed  Google Scholar 

  • Hutchinson, D. B. A., El-Sheikh, H., Jones, B. R., Anderson, J., Fuglsang, H. & MacKenzie, C. D. (1979). Adverse reactions to cutaneous diethylcarbamazine in onchocerciasis. Lancet., 2, 46.

    Article  CAS  PubMed  Google Scholar 

  • Jones, B. R., Anderson, J. & Fuglsang, H. (1978a). effects of various concentrations of diethylcarbamazine citrate applied as eye drops in ocular onchocerciasis and the possibilities of improved therapy from continuous non-pulsed delivery. Brit. J. Ophthalmol, 62, 428–439.

    Article  CAS  Google Scholar 

  • Jones, B. R., Anderson, J. & Fuglsang, H. (1978b). Evaluation of microfilaricidal effect in the cornea of topically applied drugs in ocular onchocerciasis; trials with levamisole and mebendazole. Brit. J. Ophthalmol., 62, 440–444.

    Article  CAS  Google Scholar 

  • Kale, O. (1978). Small scale trial of six drugs against O. volvulus. Tropenmed. Parasitol., 29, 163–167.

    CAS  PubMed  Google Scholar 

  • Lammler, G., Sanger, I. & Wegerhof, P. H. (1978). Chemotherapeutic studies on Litomosoides carinii infection in Mastomys natalensis 7: Filaricidal activity of furazolidone. Tropenmed. Parasitol., 29, 178–182.

    CAS  PubMed  Google Scholar 

  • Lammler, G. & Wolf, E. (1977). Chemoprophylactic activity of filaricidal compounds on Litomosoides carinii infection in Mastomys natalensis. Tropenmed. Parasitol., 28, 205–225.

    CAS  PubMed  Google Scholar 

  • Langham, M. R., Traub, Z. D. & Richardson, R. (1978). A transepidermal chemotherapy of onchocerciasis. Tropenmed. Parasitol., 29, 156–162.

    CAS  PubMed  Google Scholar 

  • Maertens, K & Wéry, M. (1975). Effect of mebendazole and levamisole on Onchocerca volvulus and Dipetalonema perstans. Trans. Roy. Soc. Trop. Med. Hygiene, 69, 359–360.

    Article  CAS  Google Scholar 

  • Martindale, W. (1977). Extra Pharmacopoeia 27th ed. p. 101. London: Pharmaceutical press.

    Google Scholar 

  • Oomen, A. P. (1969). Fatalities after treatment of onchocerciasis with diethylcarbamazine. Trans. Roy. Soc. Trop.Med. Hygiene, 63, 548.

    Article  CAS  Google Scholar 

  • Prod’hon, J., Moreau, J. P. & Mongin, C. (1979). Chimiotherapie de L’Onchocercose I: Essais de traitement de masse par le diethylcarbamazine, le levamisole et l’association diethylcarbamazine + levamisole Med. Trop., 39, 619–628.

    Google Scholar 

  • Prod’hon, J., Sainte-Marie, F. F., Moreau, J. P. & Desfontaine, M. (1979). Chimiotherapie de L’Onchocercose II: Evaluation de l’activite de deux schemas therapeutiques associant diethylcarbamazine + levamisole sur la densite microfilarienne d’Onchocerca volvulus (Leuckart, 1893). Med. Trop., 39, 631–635.

    Google Scholar 

  • Rollo, I. M. (1975). Drugs used in the chemotherapy of helminthiasis. In The Pharmacological Basis of Therapeutics, pp. 1020–1022. New York: MacMillan.

    Google Scholar 

  • Rougement, A., Boisson, M. E., Borges da Silva, G. & Zander, N. (1976). Un essai de traitement collectif par la diethylcarbamazine dans un village d’hyperendemie onchocerquienne de la region de Bamako (Mali). Bull. WHO, 54, 403–410.

    Google Scholar 

  • Rougement, A., Delmont, J., Ranque, P., Ducam, M. & Prost, A. (1979). Traitement collectif de l’onchocercose par de faibles doses de suramine dans une village hyperendemique au Mali (premiers resultats parasitologiques) Mimeographed Document WHO/ONCHO/79.147.

    Google Scholar 

  • Salazar-Mallén, M., Gonzalez-Barranco, D. & Del Carmen Montes, H. (1971b). Quimioterapia de la oncocerocosis con metrifonate. Rev. Inst. Med. Trop. Sao Paulo, 13, 363–368.

    PubMed  Google Scholar 

  • Salazar-Mallén, M., Gonzalez-Barranco, D. & Jurado Mendoza, J. (1971a). Trichlorophon treatment of onchocerciasis. Ann. Trop. Med. Parasitol., 65, 393–398.

    PubMed  Google Scholar 

  • Sowa, J. & Sowa, S. C. I. (1978). Long term treatment of onchocerciasis in children with low doses of diethylcarbamazine. Ann. Trop. Med. Parasitol., 72, 79–85.

    CAS  PubMed  Google Scholar 

  • Villamayor, C. A. (1970). Estudio para valorar la prevencion del choque terapeutico en la oncocercosis. Salud. Publ. Mex., 12, 321–331.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Onchocerciasis Chemotherapeutic Research Centre, Tamale Hospital, Tamale, Ghana

    K. Awadzi

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  1. K. Awadzi
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P. Turner C. Padgham A. Hedges

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© 1980 The contributors

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Awadzi, K. (1980). Therapy of Tropical Diseases — Filariasis. In: Turner, P., Padgham, C., Hedges, A. (eds) Clinical Pharmacology & Therapeutics. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05952-2_52

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