Skip to main content

Abstract

Human skin is capable of metabolising a variety of drugs and other compounds (Pannatier, Jenner, Testa & Etter, 1978) (Table 1). Our interest has been concerned particularly, with aryl hydrocarbon hydroxylase (EC 1.14.14.2; AHH), and more recently with epoxide hydratase (EC.4.2.1.63; EH) and the hydrolysis of steroid esters.

Drug metabolism by human skin

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Alvares, A. P., Kappas, A., Levin, W. & Conney, A. H. (1973). Inducibility of benz(α)pyrene hydroxylase in human skin by polycyclic hydrocarbons. Clin. Pharmac. Ther., 14, 30–39.

    CAS  Google Scholar 

  • Amos, H. E. (1976). Allergic drug reactions. London: Edward Arnold.

    Google Scholar 

  • Chapman, P. H., Moss, C., Keys, B., Shuster, S. & Rawlins, M. D. (1980). Antipyrine clearance in psoriasis. Brit. med. J., in press.

    Google Scholar 

  • Chapman, P. H., Rawlins, M. D. & Shuster, S. (1979a). The activity of aryl hydrocarbon hydroxylase in adult human skin. Brit. J. clin. Pharmac. 7, 499–503.

    Article  CAS  Google Scholar 

  • Chapman, P. H., Rawlins, M. D. & Shuster, S. (1979b). Activity of aryl hydrocarbon hydroxylase in psoriatic skin. Lancet, 1, 297–298.

    Article  CAS  PubMed  Google Scholar 

  • Crooks, J., O’Malley, K. & Stephenson, I. H. (1976). Pharmacokinetics in the elderly. Clin. Pharmacokin., 1, 280–296.

    Article  CAS  Google Scholar 

  • Engin, A. (1976). Glutathione content of human skin carcinomas. Arch. Derm. Res., 257, 53–55.

    Article  CAS  Google Scholar 

  • Falk, H. L. & Kolin, P. (1963). Chemistry, host entry, and metabolic fate of carcinogens. Clin. Pharmac. Ther., 4, 88–103.

    Google Scholar 

  • Fox, C. H., Selkirk, J. K., Price, F. M., Croy, R. G., Sanford, K. K. & Cottier-Fox, M. (1975). Metabolism of benzo(α)pyrene by human epithelial cells in vitro. Cancer Res., 35, 3551–3555.

    CAS  PubMed  Google Scholar 

  • Gelboin, H. V. (1977). Cancer susceptibility and carcinogen metabolism. New Eng. J. Med., 297, 384–385.

    Article  CAS  PubMed  Google Scholar 

  • Kapitulnik, J., Levin, W., Lu, A. Y. H., Morecki, R., Dansette, P. M., Jerina, D. M. & Conney, A. H. (1977). Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes. Clin. Pharmac. Ther., 21, 158–165.

    CAS  Google Scholar 

  • Kersey, P., Chapman, P. H., Shuster, S. & Rawlins, M. D. (1980). Activity of AHH in skin disease. Scot. med. J., in press.

    Google Scholar 

  • Kocsard, E. (1976). The rarity of solar keratoses in psoriatic patients: preliminary report. Aust. J. Derm., 17, 65–67.

    Article  CAS  Google Scholar 

  • Mukhtar, H. (1976). Glutathione-S-epoxide transferase in mouse skin and human foreskin. J. invest. Derm., 66, 161–164.

    Article  CAS  PubMed  Google Scholar 

  • O’Neill, V. A., Chapman, P. H. & Rawlins, M. D. (1980). Epoxide hydrase activity in human skin. First World Conference, Clin. Pharmac. Abstract no. 0950.

    Google Scholar 

  • Pannatier, A., Jenner, P., Testa, B. & Etter, J. C. (1978). The skin as a drug-metabolising organ. Drug. Met. Rev., 8, 319–343.

    Article  CAS  Google Scholar 

  • Pelkonen, O. (1976). Metabolism of benz(α)pyrene in human adult and foetal tissues. In Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, eds. Freudenthal, R. L. & Jones, P. W., pp. 9–21. New York: Raven Press.

    Google Scholar 

  • Rawlins, M. D., Shaw, V. & Shuster, S. (1979). The in vitro metabolism of betamethasone-17-alerate by human skin. Brit. J. clin. Pharmac, 8, 441 P.

    Article  Google Scholar 

  • Shaw, V. A., Jones, H., Shuster, S. & Rawlins, M. D. (1980). In vitro hydrolysis of betaethasone esters by human tissues. First World Conference Clin. Pharmac. Abstract no. 0476.

    Google Scholar 

  • Shuster, S., Chapman, P. H. & Rawlins, M. D. (1979). Psoriasis and skin cancer. Brit. med. J., 2, 941–942.

    Article  Google Scholar 

  • Shuster, S., Rawlins, M. D., Chapman, P. H. & Rogers, S. (1980). Decreased epidermal AHH and located pustular psoriasis. Brit. J. Derm., in press.

    Google Scholar 

  • Sims, P. & Grover, P. L. (1974). Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. Adv. Cancer Res., 20, 164–174.

    Google Scholar 

  • Sims, P., Grover, P. L., Swaisland, A., Pal, K. & Hewer, A. (1974). Metabolic activation of benz(α)pyrene proceeds by a diol-epoxide. Nature, 252, 326–328.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

P. Turner C. Padgham A. Hedges

Copyright information

© 1980 The contributors

About this chapter

Cite this chapter

Rawlins, M.D., Shuster, S., Chapman, P.H., Shaw, V., O’Neill, V.A. (1980). Drug Metabolism in Skin. In: Turner, P., Padgham, C., Hedges, A. (eds) Clinical Pharmacology & Therapeutics. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05952-2_46

Download citation

Publish with us

Policies and ethics