Abstract
Human skin is capable of metabolising a variety of drugs and other compounds (Pannatier, Jenner, Testa & Etter, 1978) (Table 1). Our interest has been concerned particularly, with aryl hydrocarbon hydroxylase (EC 1.14.14.2; AHH), and more recently with epoxide hydratase (EC.4.2.1.63; EH) and the hydrolysis of steroid esters.
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References
Alvares, A. P., Kappas, A., Levin, W. & Conney, A. H. (1973). Inducibility of benz(α)pyrene hydroxylase in human skin by polycyclic hydrocarbons. Clin. Pharmac. Ther., 14, 30–39.
Amos, H. E. (1976). Allergic drug reactions. London: Edward Arnold.
Chapman, P. H., Moss, C., Keys, B., Shuster, S. & Rawlins, M. D. (1980). Antipyrine clearance in psoriasis. Brit. med. J., in press.
Chapman, P. H., Rawlins, M. D. & Shuster, S. (1979a). The activity of aryl hydrocarbon hydroxylase in adult human skin. Brit. J. clin. Pharmac. 7, 499–503.
Chapman, P. H., Rawlins, M. D. & Shuster, S. (1979b). Activity of aryl hydrocarbon hydroxylase in psoriatic skin. Lancet, 1, 297–298.
Crooks, J., O’Malley, K. & Stephenson, I. H. (1976). Pharmacokinetics in the elderly. Clin. Pharmacokin., 1, 280–296.
Engin, A. (1976). Glutathione content of human skin carcinomas. Arch. Derm. Res., 257, 53–55.
Falk, H. L. & Kolin, P. (1963). Chemistry, host entry, and metabolic fate of carcinogens. Clin. Pharmac. Ther., 4, 88–103.
Fox, C. H., Selkirk, J. K., Price, F. M., Croy, R. G., Sanford, K. K. & Cottier-Fox, M. (1975). Metabolism of benzo(α)pyrene by human epithelial cells in vitro. Cancer Res., 35, 3551–3555.
Gelboin, H. V. (1977). Cancer susceptibility and carcinogen metabolism. New Eng. J. Med., 297, 384–385.
Kapitulnik, J., Levin, W., Lu, A. Y. H., Morecki, R., Dansette, P. M., Jerina, D. M. & Conney, A. H. (1977). Hydration of arene and alkene oxides by epoxide hydrase in human liver microsomes. Clin. Pharmac. Ther., 21, 158–165.
Kersey, P., Chapman, P. H., Shuster, S. & Rawlins, M. D. (1980). Activity of AHH in skin disease. Scot. med. J., in press.
Kocsard, E. (1976). The rarity of solar keratoses in psoriatic patients: preliminary report. Aust. J. Derm., 17, 65–67.
Mukhtar, H. (1976). Glutathione-S-epoxide transferase in mouse skin and human foreskin. J. invest. Derm., 66, 161–164.
O’Neill, V. A., Chapman, P. H. & Rawlins, M. D. (1980). Epoxide hydrase activity in human skin. First World Conference, Clin. Pharmac. Abstract no. 0950.
Pannatier, A., Jenner, P., Testa, B. & Etter, J. C. (1978). The skin as a drug-metabolising organ. Drug. Met. Rev., 8, 319–343.
Pelkonen, O. (1976). Metabolism of benz(α)pyrene in human adult and foetal tissues. In Polynuclear Aromatic Hydrocarbons: Chemistry, Metabolism and Carcinogenesis, eds. Freudenthal, R. L. & Jones, P. W., pp. 9–21. New York: Raven Press.
Rawlins, M. D., Shaw, V. & Shuster, S. (1979). The in vitro metabolism of betamethasone-17-alerate by human skin. Brit. J. clin. Pharmac, 8, 441 P.
Shaw, V. A., Jones, H., Shuster, S. & Rawlins, M. D. (1980). In vitro hydrolysis of betaethasone esters by human tissues. First World Conference Clin. Pharmac. Abstract no. 0476.
Shuster, S., Chapman, P. H. & Rawlins, M. D. (1979). Psoriasis and skin cancer. Brit. med. J., 2, 941–942.
Shuster, S., Rawlins, M. D., Chapman, P. H. & Rogers, S. (1980). Decreased epidermal AHH and located pustular psoriasis. Brit. J. Derm., in press.
Sims, P. & Grover, P. L. (1974). Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. Adv. Cancer Res., 20, 164–174.
Sims, P., Grover, P. L., Swaisland, A., Pal, K. & Hewer, A. (1974). Metabolic activation of benz(α)pyrene proceeds by a diol-epoxide. Nature, 252, 326–328.
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Rawlins, M.D., Shuster, S., Chapman, P.H., Shaw, V., O’Neill, V.A. (1980). Drug Metabolism in Skin. In: Turner, P., Padgham, C., Hedges, A. (eds) Clinical Pharmacology & Therapeutics. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05952-2_46
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DOI: https://doi.org/10.1007/978-1-349-05952-2_46
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