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Drug Treatment of Depression

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Current Themes in Psychiatry 1

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Abstract

Depressive illness is the most common affective disorder and the range of disturbance that patients may present with is extremely wide. In its mildest form it may be very difficult to distinguish between apparently normal feelings of disappointment, frustration and unhappiness and morbid depression. At the other extreme, urgent measures are indicated for psychotic symptoms, depressive stupor and suicidal intent. The depressive syndrome also leads to considerable morbidity with impairment of domestic, social and occupational aspects of life. However, with regard to therapy, the tricyclic compounds and monoamine oxidase inhibitors (MAOIs) introduced almost 20 years ago, have proved to be effective and relatively safe treatments. The tricyclic compounds still remain the most popular antidepressant medication although the prescription of minor tranquillisers for mild depressive reactions is a recent trend and lithium has become established as the drug of choice for stabilisation of manic depressive illness. The tetracyclic compounds, L-tryptophan and low dose neuroleptics are all relatively new antidepressant treatments that are still being evaluated clinically.

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© 1978 Raghu N. Gaind and Barbara L. Hudson

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Barnes, T., Braithwaite, R. (1978). Drug Treatment of Depression. In: Current Themes in Psychiatry 1. Palgrave, London. https://doi.org/10.1007/978-1-349-03642-4_28

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  • DOI: https://doi.org/10.1007/978-1-349-03642-4_28

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-03644-8

  • Online ISBN: 978-1-349-03642-4

  • eBook Packages: MedicineMedicine (R0)

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