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Biomarkers for Alzheimer’s Disease Drug Development

  • Book
  • © 2024

Overview

Editors:
  1. Robert Perneczky

    1. Department of Psychiatry and Psychotherapy, LMU Hospital, Ludwig-Maximilians-University Munich, Munich, Germany

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2785)

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Table of contents (20 protocols)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Strategies to Improve Alzheimer’s Disease Biomarkers

    1. Front Matter

      Pages 1-1
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    2. Blood-Based Biomarkers for Early Alzheimer’s Disease Diagnosis in Real-World Settings

      • Robert Perneczky, Niels Hansen, Anna Hofmann, Christoph Laske, Josef Priller, Timo Grimmer et al.
      Pages 3-14

    3. Alzheimer’s Disease Prevention and Treatment Based on Population-Based Approaches

      • Robert Perneczky
      Pages 15-33

  3. Innovative Fluid Biomarkers

    1. Front Matter

      Pages 35-35
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    2. CSF N-Glycomics Using High-Throughput UPLC-ESI Techniques in Alzheimer’s Disease

      • Angela Messina, Rita Barone, Luisa Sturiale, Mario Zappia, Angelo Palmigiano, Domenico Garozzo
      Pages 37-48

    3. CSF N-Glycomics Using MALDI MS Techniques

      • Angela Messina, Donata Agata Romeo, Rita Barone, Luisa Sturiale, Angelo Palmigiano, Mario Zappia et al.
      Pages 49-65

    4. Optimized Pre-analytical Handling Protocol for Blood-Based Biomarkers of Alzheimer’s Disease

      • Alexander Jethwa, Laura Stöckl
      Pages 67-73

    5. Mass Spectrometry-Based Metabolomics Multi-platform for Alzheimer’s Disease Research

      • Álvaro González-Domínguez, Ana Sayago, Ángeles Fernández-Recamales, Raúl González-Domínguez
      Pages 75-86

  4. Magnetic Resonance Imaging Methods

    1. Front Matter

      Pages 87-87
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    2. Analysis of Resting-State Functional Magnetic Resonance Imaging in Alzheimer’s Disease

      • Ersin Ersözlü, Boris-Stephan Rauchmann
      Pages 89-104

    3. Diffusion Tensor Imaging in Alzheimer’s Studies

      • Adriana L. Ruiz-Rizzo, Kathrin Finke, Mario E. Archila-Meléndez
      Pages 105-113

    4. Magnetic Resonance Spectroscopy (MRS) in Alzheimer’s Disease

      • Nasim Sheikh-Bahaei
      Pages 115-142

    5. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies

      • Carles Falcon, Grégory Operto, José Luis Molinuevo, Juan Domingo Gispert
      Pages 143-162

  5. Molecular Imaging Approaches

    1. Front Matter

      Pages 163-163
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    2. Amyloid PET Imaging: Standard Procedures and Semiquantification

      • Francesca D’Amico, Luca Sofia, Matteo Bauckneht, Silvia Morbelli
      Pages 165-175

    3. PET Imaging to Measure Neuroinflammation In Vivo

      • Maura Malpetti, Nicolai Franzmeier, Matthias Brendel
      Pages 177-193

    4. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach

      • Elena Rodriguez-Vieitez, Amit Kumar, Mona-Lisa Malarte, Konstantinos Ioannou, Filipa M. Rocha, Konstantinos Chiotis
      Pages 195-218

  6. Neuropathology

    1. Front Matter

      Pages 219-219
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    2. High-Throughput Lipidomic and Metabolomic Profiling for Brain Tissue and Biofluid Samples in Neurodegenerative Disorders

      • Bonne M. Thompson, Giuseppe Astarita
      Pages 221-260
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Keywords

About this book

This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. 

Authoritative and practical, Biomarkers for Alzheimer’s Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease.

Editors and Affiliations

  • Department of Psychiatry and Psychotherapy, LMU Hospital, Ludwig-Maximilians-University Munich, Munich, Germany

    Robert Perneczky

Bibliographic Information

  • Book Title: Biomarkers for Alzheimer’s Disease Drug Development

  • Editors: Robert Perneczky

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-3774-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024

  • Hardcover ISBN: 978-1-0716-3773-9Published: 02 March 2024

  • Softcover ISBN: 978-1-0716-3776-0Due: 05 June 2024

  • eBook ISBN: 978-1-0716-3774-6Published: 01 March 2024

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XII, 347

  • Number of Illustrations: 2 b/w illustrations, 49 illustrations in colour

  • Topics: Biomedicine, general, Neurosciences, Neurosciences

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