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Mechanistic Model-Driven Biodesign in Mammalian Synthetic Biology

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Mammalian Synthetic Systems

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2774))

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Abstract

Mathematical modeling plays a vital role in mammalian synthetic biology by providing a framework to design and optimize design circuits and engineered bioprocesses, predict their behavior, and guide experimental design. Here, we review recent models used in the literature, considering mathematical frameworks at the molecular, cellular, and system levels. We report key challenges in the field and discuss opportunities for genome-scale models, machine learning, and cybergenetics to expand the capabilities of model-driven mammalian cell biodesign.

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Acknowledgments

LM was funded by the Engineering and Physical Sciences Research Council (EPSRC, EP/S01876X/1) and the Biotechnology and Biological Sciences Research Council (BBSRC, Bristol Centre for Engineering Biology, BB/W013959/1; Breakthrough Award BB/W012235/1).

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Authors and Affiliations

  1. School of Mathematics, University of Birmingham, Birmingham, UK

    Yin Hoon Chew

  2. Department of Engineering Mathematics, University of Bristol, Bristol, UK

    Lucia Marucci

  3. School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK

    Lucia Marucci

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  1. Yin Hoon Chew
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  2. Lucia Marucci
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Correspondence to Lucia Marucci .

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Editors and Affiliations

  1. Department of Chemical Engineering and Imperial College Centre for Synthetic Biology, Imperial College London, London, UK

    Francesca Ceroni

  2. Department of Chemical Engineering and Imperial College Centre for Synthetic Biology, Imperial College London, London, UK

    Karen Polizzi

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Chew, Y.H., Marucci, L. (2024). Mechanistic Model-Driven Biodesign in Mammalian Synthetic Biology. In: Ceroni, F., Polizzi, K. (eds) Mammalian Synthetic Systems. Methods in Molecular Biology, vol 2774. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3718-0_6

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  • DOI: https://doi.org/10.1007/978-1-0716-3718-0_6

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