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Reverse Translation to Develop Post-stroke Therapeutic Interventions during Mechanical Thrombectomy: Lessons from the BACTRAC Trial

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Neural Repair

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2616))

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Abstract

The majority of strokes, approximately 87%, are ischemic in etiology with the remaining hemorrhagic in origin. Emergent large vessel occlusions (ELVOs) are a subtype of ischemic stroke accounting for approximately 30–40% of acute large vessel blockages. Treatment for ELVOs focuses on recanalization of the occluded vessel by time-sensitive administration of tissue plasminogen activator (tPA) or thrombus removal using mechanical thrombectomy. Although a great deal of time and resources have focused on translational stroke research, little progress has been made in the area of identifying additional new treatments for stroke. Translational limitations include difficulty simulating human comorbid conditions in animal models, as well as the temporal nature of stroke pathology. The Blood And Clot Thrombectomy Registry And Collaboration represents an ongoing tissue registry for thrombectomy patients and includes collection of intracranial arterial blood, systemic arterial blood, thrombi, as well as a series of clinical and radiographic data points for analysis. This chapter will explore the methodologies employed and results obtained from studying BACTRAC-derived human biological specimens and how they can inform translational experimental design in animal studies.

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Author information

Authors and Affiliations

  1. Department of Neurology, Department of Neuroscience, The University of Kentucky, Lexington, KY, USA

    Benton Maglinger, Jacqueline A. Frank, Justin F. Fraser & Keith R. Pennypacker

  2. Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, KY, USA

    Jacqueline A. Frank, Justin F. Fraser & Keith R. Pennypacker

  3. Department of Neurosurgery, University of Kentucky, Lexington, KY, USA

    Justin F. Fraser

  4. Department of Radiology, University of Kentucky, Lexington, KY, USA

    Justin F. Fraser

  5. Department of Neuroscience, University of Kentucky, Lexington, KY, USA

    Justin F. Fraser

Authors
  1. Benton Maglinger
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  2. Jacqueline A. Frank
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  3. Justin F. Fraser
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  4. Keith R. Pennypacker
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Corresponding author

Correspondence to Keith R. Pennypacker .

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA

    Vardan T. Karamyan

  2. Department of Neurology, Department of Neuroscience, The University of Kentucky, Lexington, KY, USA

    Ann M. Stowe

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Maglinger, B., Frank, J.A., Fraser, J.F., Pennypacker, K.R. (2023). Reverse Translation to Develop Post-stroke Therapeutic Interventions during Mechanical Thrombectomy: Lessons from the BACTRAC Trial. In: Karamyan, V.T., Stowe, A.M. (eds) Neural Repair. Methods in Molecular Biology, vol 2616. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2926-0_27

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  • DOI: https://doi.org/10.1007/978-1-0716-2926-0_27

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2925-3

  • Online ISBN: 978-1-0716-2926-0

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