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Pharmacogenomics in Drug Discovery and Development

  • Book
  • © 2022
  • Latest edition

Overview

Editors:
  1. Qing Yan

    1. PharmTao, Santa Clara, USA

    View editor publications

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2547)

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Table of contents (22 protocols)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Target Discovery for Drug Development Using Mendelian Randomization

    • Daniel S. Evans
    Pages 1-20

  3. Human Leukocyte Antigen (HLA) Testing in Pharmacogenomics

    • Ann M. Moyer, Manish J. Gandhi
    Pages 21-45

  4. Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer

    • Zahra Talebi, Alex Sparreboom, Susan I. Colace
    Pages 47-61

  5. Pharmacogenomics in Cytotoxic Chemotherapy of Cancer

    • Zahra Talebi, Alex Sparreboom, Susan I. Colace
    Pages 63-94

  6. Management of Side Effects in the Personalized Medicine Era: Chemotherapy-Induced Peripheral Neurotoxicity

    • Eleonora Pozzi, Paola Alberti
    Pages 95-140

  7. The Yin-Yang Dynamics in Cancer Pharmacogenomics and Personalized Medicine

    • Qing Yan
    Pages 141-163

  8. Design of Personalized Neoantigen RNA Vaccines Against Cancer Based on Next-Generation Sequencing Data

    • Begoña Alburquerque-González, María Dolores López-Abellán, Ginés Luengo-Gil, Silvia Montoro-García, Pablo Conesa-Zamora
    Pages 165-185

  9. COVID-19 Pharmacotherapy: Drug Development, Repurposing of Drugs, and the Role of Pharmacogenomics

    • Rebecca Bock, Mariana Babayeva, Zvi G. Loewy
    Pages 187-199

  10. Pharmacogenomics Informs Cardiovascular Pharmacotherapy

    • Mariana Babayeva, Brigitte Azzi, Zvi G. Loewy
    Pages 201-240

  11. Pharmacogenomic Screening of Drug Candidates using Patient-Specific hiPSC-Derived Cardiomyocyte High-Throughput Calcium Imaging

    • Malorie Blancard, K. Ashley Fetterman, Paul W. Burridge
    Pages 241-253

  12. The Yin-Yang Dynamics in Cardiovascular Pharmacogenomics and Personalized Medicine

    • Qing Yan
    Pages 255-266

  13. GTPγS Assay for Measuring Agonist-Induced Desensitization of Two Human Polymorphic Alpha2B-Adrenoceptor Variants

    • Jordana I. Borges, Alexandra M. Carbone, Natalie Cora, Anastasiya Sizova, Anastasios Lymperopoulos
    Pages 267-273

  14. Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development

    • Ramón Cacabelos, Vinogran Naidoo, Olaia Martínez-Iglesias, Lola Corzo, Natalia Cacabelos, Rocío Pego et al.
    Pages 275-387

  15. Pharmacogenetics of Antipsychotic Treatment in Schizophrenia

    • Samar S. M. Elsheikh, Daniel J. Müller, Jennie G. Pouget
    Pages 389-425

  16. The Pharmacogenetic Impact on the Pharmacokinetics of ADHD Medications

    • Jacob T. Brown
    Pages 427-436

  17. Pharmacogenetics of Addiction Therapy

    • David P. Graham, Mark J. Harding, David A. Nielsen
    Pages 437-490

  18. Pharmacogenomics of Opioid Treatment for Pain Management

    • Sarahbeth Howes, Alexandra R. Cloutet, Jaeyeon Kweon, Taylor L. Powell, Daniel Raza, Elyse M. Cornett et al.
    Pages 491-504

  19. The Role of Pharmacogenomics in Postoperative Pain Management

    • E. Paylor Sachtleben, Kelsey Rooney, Hannah Haddad, Victoria L. Lassiegne, Megan Boudreaux, Elyse M. Cornett et al.
    Pages 505-526

  20. Pharmacogenetics of Drug Therapies in Rheumatoid Arthritis

    • Atinuke Aluko, Prabha Ranganathan
    Pages 527-567
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Keywords

About this book

This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. 

Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.

Editors and Affiliations

  • PharmTao, Santa Clara, USA

    Qing Yan

Bibliographic Information

  • Book Title: Pharmacogenomics in Drug Discovery and Development

  • Editors: Qing Yan

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2573-6

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2022

  • Hardcover ISBN: 978-1-0716-2572-9Published: 07 September 2022

  • Softcover ISBN: 978-1-0716-2575-0Published: 08 September 2023

  • eBook ISBN: 978-1-0716-2573-6Published: 06 September 2022

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 3

  • Number of Pages: XIV, 616

  • Number of Illustrations: 7 b/w illustrations, 47 illustrations in colour

  • Topics: Pharmacology/Toxicology, Genetics and Genomics, Medicinal Chemistry

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