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Integration of DNA Microarray with Clinical and Genomic Data

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Microarray Data Analysis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2401))

Abstract

DNA microarrays have been widely employed to understand cancer development. This technology is able to measure expression levels of a large numbers of genes or to genotype multiple regions of a genome in a massively parallel experiment. In addition, the detection of methylation patterns and gene copy number variations are also performed. Clinicians began to apply these findings in personalized medicine for the selection of cancer therapy according to the individual’s cancer genomic profile. Because cancer is a complex disease it is of great value to integrate microarray data with genomic and clinical data. Here, we presented an overview of DNA microarray technology and discuss about benefits and challenging of microarray data integration.

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Author information

Authors and Affiliations

  1. Institute for Biomedical Research and Innovation (IRIB), National Research Council (CNR), Messina, Italy

    Francesca Scionti

  2. Institute for Biomedical Research and Innovation (IRIB-CNR), Section of Catanzaro, Catanzaro, Italy

    Mariamena Arbitrio

  3. Department of Experimental and Clinical Medicine, Magna Græcia University, Catanzaro, Italy

    Daniele Caracciolo, Pierfrancesco Tassone, Pierosandro Tagliaferri & Maria Teresa Di Martino

  4. Department of Medical and Surgical Sciences, Pediatric Unit, Magna Græcia University, Catanzaro, Italy

    Licia Pensabene

Authors
  1. Francesca Scionti
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  2. Mariamena Arbitrio
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  3. Daniele Caracciolo
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  4. Licia Pensabene
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  5. Pierfrancesco Tassone
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  6. Pierosandro Tagliaferri
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  7. Maria Teresa Di Martino
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Corresponding author

Correspondence to Maria Teresa Di Martino .

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Editors and Affiliations

  1. Dipartimento di Giurisprudenza, Economia e Sociologia, Università degli Studi “Magna Graecia” di Catanzaro, Catanzaro, Italy

    Giuseppe Agapito

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Scionti, F. et al. (2022). Integration of DNA Microarray with Clinical and Genomic Data. In: Agapito, G. (eds) Microarray Data Analysis. Methods in Molecular Biology, vol 2401. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1839-4_15

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  • DOI: https://doi.org/10.1007/978-1-0716-1839-4_15

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1838-7

  • Online ISBN: 978-1-0716-1839-4

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