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Alteration of Flavin Cofactor Homeostasis in Human Neuromuscular Pathologies

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Flavins and Flavoproteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2280))

Abstract

The aim of this short review chapter is to provide a brief summary of the relevance of riboflavin (Rf or vitamin B2) and its derived cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) for human neuromuscular bioenergetics.

Therefore, as a completion of this book we would like to summarize what kind of human pathologies could derive from genetic disturbances of Rf transport, flavin cofactor synthesis and delivery to nascent apoflavoproteins, as well as by alteration of vitamin recycling during protein turnover.

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Acknowledgments

This work was funded by a grant from Cure RTD (Year 2019) http://curertd.org/news/new/ “Alterations of Rf transport and metabolism in Brown-Vialetto-Van-Laere Syndrome (BVVLS)” (to M.B.).

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  1. Department of Biosciences, Biotechnology and Biopharmaceutics, University of Bari “A. Moro”, Bari, Italy

    Maria Tolomeo, Alessia Nisco & Maria Barile

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  1. Maria Tolomeo
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  2. Alessia Nisco
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    Maria Barile

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Tolomeo, M., Nisco, A., Barile, M. (2021). Alteration of Flavin Cofactor Homeostasis in Human Neuromuscular Pathologies. In: Barile, M. (eds) Flavins and Flavoproteins. Methods in Molecular Biology, vol 2280. Springer, New York, NY. https://doi.org/10.1007/978-1-0716-1286-6_18

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