Abstract
The estimation of dose in an experiment influences the results strongly. Hence the effective dose fixation in animal studies, which is an inevitable part in drug research, is significant as it varies among species. Hence the pharmacokinetics and pharmacodynamics need to consider on dose fixation and various methods are available for this, few of which are described in this chapter. The conversion based on normalization of dose-to-body surface area and animal equivalent dose determination is explained with the guidelines for calculations.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Erhirhie EO, Ekene NE, Ajaghaku DL (2014) Guidelines on dosage calculation and stock solution preparation in experimental animals’ studies. J Nat Sci Res 4(18):100–106
Nair AB, Jacob S (2016) A simple practice guide for dose conversion between animals and human. J Basic Clin Pharm 7(2):27
Nair A, Morsy MA, Jacob S (2018) Dose translation between laboratory animals and human in preclinical and clinical phases of drug development. Drug Dev Res 79(8):373–382
OECD (2000) Guidance document on acute oral toxicity. Environ Health Safety Monogr Ser Test Assess 2000:24
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Science+Business Media, LLC , part of Springer Nature
About this protocol
Cite this protocol
Arunachalam, K., Sasidharan, S.P. (2021). Preclinical Drug Dose Calculation. In: Bioassays in Experimental and Preclinical Pharmacology. Springer Protocols Handbooks. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1233-0_4
Download citation
DOI: https://doi.org/10.1007/978-1-0716-1233-0_4
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-1232-3
Online ISBN: 978-1-0716-1233-0
eBook Packages: Springer Protocols