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Inorganic Nanoparticles and Their Strategies to Enhance Brain Drug Delivery

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Nanomedicines for Brain Drug Delivery

Part of the book series: Neuromethods ((NM,volume 157))

Abstract

The main obstacle for brain drug delivery after systemic administration is the presence of the blood-brain barrier (BBB). The use of drug nanocarriers to overcome this selective barrier that isolates the central nervous system (CNS) has been widely studied in recent years. Among the different nanoparticles described in literature, inorganic nanoparticles such as gold, iron oxide, carbon, silver, and others have been studied for brain drug delivery. Here, we describe the strategies employed with different inorganic nanoparticles to reach the CNS, which in general used targeting molecules that can facilitate the transport across the BBB through transport mechanisms such as adsorptive-mediated transcytosis and receptor-mediated transport or the use of peptide vectors. Throughout this chapter, examples of diverse nanosystems will be given, highlighting the main research objectives, their characteristics, and the results obtained.

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Acknowledgments

Fondap 15130011 and Fondecyt 1170929.

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Authors and Affiliations

  1. Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile

    Eduardo Gallardo-Toledo, Carolina Velasco-Aguirre & Marcelo Javier Kogan

  2. Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile

    Eduardo Gallardo-Toledo, Carolina Velasco-Aguirre & Marcelo Javier Kogan

Authors
  1. Eduardo Gallardo-Toledo
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  2. Carolina Velasco-Aguirre
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  3. Marcelo Javier Kogan
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Correspondence to Eduardo Gallardo-Toledo or Marcelo Javier Kogan .

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Editors and Affiliations

  1. Department of Pharmaceutical Science and Technology, University of Chile, Santiago, Chile

    Javier O. Morales

  2. 2-BBB Medicines BV, Leiden, The Netherlands

    Pieter J. Gaillard

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Gallardo-Toledo, E., Velasco-Aguirre, C., Kogan, M.J. (2021). Inorganic Nanoparticles and Their Strategies to Enhance Brain Drug Delivery. In: Morales, J.O., Gaillard, P.J. (eds) Nanomedicines for Brain Drug Delivery. Neuromethods, vol 157. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0838-8_6

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  • DOI: https://doi.org/10.1007/978-1-0716-0838-8_6

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