Skip to main content

Radiotherapy for Thoracic Esophageal Squamous Cell Carcinoma

  • Protocol
  • First Online:
Esophageal Squamous Cell Carcinoma

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2129))

Abstract

Esophageal squamous cell carcinoma (ESCC) is an aggressive disease. Many patients have locally advanced disease or already have distant metastasis at presentation. Radiotherapy plays an important role in the treatment of esophageal squamous cell carcinoma. Neoadjuvant chemoradiotherapy improves the survival and surgical outcome compared to surgery alone. Definitive radiotherapy (RT) with or without chemotherapy is used in patients who decline surgery or are medically inoperable. Palliative radiotherapy using external beam radiotherapy or intraluminal brachytherapy is effective for dysphagia and pain control.d

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ding X, Zhang J, Li B, Wang Z, Huang W, Zhou T, Wei Y, Li H (2012) A meta-analysis of lymph node metastasis rate for patients with thoracic oesophageal cancer and its implication in delineation of clinical target volume for radiation therapy. Br J Radiol 85:e1110–e1119. https://doi.org/10.1259/bjr/12500248

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wouters MW, Gooiker GA, van Sandick JW, Tollenaar RA (2012) The volume-outcome relation in the surgical treatment of esophageal cancer: a systematic review and meta-analysis. Cancer 118:1754–1763. https://doi.org/10.1002/cncr.26383

    Article  PubMed  Google Scholar 

  3. Arnott SJ, Duncan W, Gignoux M, Hansen HS, Launois B, Nygaard K, Parmar MK, Rousell A, Spilopoulos G, Stewart G, Tierney JF, Wang M, Rhugang Z, Oeosphageal Cancer Collaborative Group (2005) Preoperative radiotherapy for esophageal carcinoma. Cochrane Database Syst Rev 4:CD001799

    Google Scholar 

  4. Zhao X, Ren Y, Hu Y, Cui N, Wang X, Cui Y (2018) Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the esophagus or the gastroesophageal junction: a meta-analysis based on clinical trials. PLoS One 13:e0202185. https://doi.org/10.1371/journal.pone.0202185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Courrech Staal EF, Aleman BM, Boot H, van Velthuysen ML, van Tinteren H, van Sandick JW (2010) Systematic review of the benefits and risks of neoadjuvant chemoradiation for oesophageal cancer. Br J Surg 97:1482–1496. https://doi.org/10.1002/bjs.7175

    Article  CAS  PubMed  Google Scholar 

  6. van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A, CROSS Group (2012) Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 366:2074–2084. https://doi.org/10.1056/NEJMoa1112088

    Article  PubMed  Google Scholar 

  7. Shapiro J, van Lanschot JJB, Hulshof MCCM, van Hagen P, van Berge Henegouwen MI, Wijnhoven BPL, van Laarhoven HWM, Nieuwenhuijzen GAP, Hospers GAP, Bonenkamp JJ, Cuesta MA, Blaisse RJB, Busch ORC, Ten Kate FJW, Creemers GM, Punt CJA, Plukker JTM, Verheul HMW, Bilgen EJS, van Dekken H, van der Sangen MJC, Rozema T, Biermann K, Beukema JC, Piet AHM, van Rij CM, Reinders JG, Tilanus HW, Steyerberg EW, van der Gaast A, CROSS study group (2015) Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol 16:1090–1098. https://doi.org/10.1016/S1470-2045(15)00040-6

    Article  PubMed  Google Scholar 

  8. Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z, Mao W, Xiang J, Han Y, Chen Z, Yang H, Wang J, Pang Q, Zheng X, Yang H, Li T, Lordick F, D'Journo XB, Cerfolio RJ, Korst RJ, Novoa NM, Swanson SJ, Brunelli A, Ismail M, Fernando HC, Zhang X, Li Q, Wang G, Chen B, Mao T, Kong M, Guo X, Lin T, Liu M, Fu J, AME Thoracic Surgery Collaborative Group (2018) Neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced squamous cell carcinoma of the esophagus (NEOCRETEC5010): a phase III multicenter, randomized, open-label clinical trial. J Clin Oncol 36:2796–2803. https://doi.org/10.1200/JCO.2018.79.1483

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Huang RW, Chao YK, Wen YW, Chang HK, Tseng CK, Chan SC, Liu YH (2014) Predictors of pathological complete response to neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma. World J Surg Oncol 12:170. https://doi.org/10.1186/1477-7819-12-170

    Article  PubMed  PubMed Central  Google Scholar 

  10. Tan Z, Yang H, Wen J, Luo K, Liu Q, Hu Y, Zhang L, Liu M, Yun J, Fu J (2018) Clinical predictors of pathologically response after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma: long term outcomes of a phase II study. J Thorac Dis 10:5254–5259. https://doi.org/10.21037/jtd.2018.08.88

    Article  PubMed  PubMed Central  Google Scholar 

  11. Cooper JS, Guo MD, Herskovic A, Macdonald JS, Martenson JA Jr, Al-Sarraf M, Byhardt R, Russell AH, Beitler JJ, Spencer S, Asbell SO, Graham MV, Leichman LL (1999) Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA 281:1623–1627

    Article  CAS  PubMed  Google Scholar 

  12. Minsky BD, Pajak TF, Ginsberg RJ, Pisansky TM, Martenson J, Komaki R, Okawara G, Rosenthal SA, Kelsen DP (2002) INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy. J Clin Oncol 20:1167–1174

    Article  CAS  PubMed  Google Scholar 

  13. Royal College of Radiologists. Radiation Dose Fractionation, second edition (2017). https://www.rcr.ac.uk/system/files/publication/field_publication_files/bfco163_dose_fractionation_2nd_ed_march2017.pdf

  14. Malthaner RA, Wong RK, Rumble RB, Zuraw L, Members of the Gastrointestinal Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care (2004) Neoadjuvant or adjuvant therapy for resectable esophageal cancer: a systematic review and meta-analysis. BMC Med 2:35

    Article  PubMed  PubMed Central  Google Scholar 

  15. Dai Y, Li C, Xie Y, Liu X, Zhang J, Zhou J, Pan X, Yang S (2014) Interventions for dysphagia in oesophageal cancer. Cochrane Database Syst Rev 10:CD005048. https://doi.org/10.1002/14651858.CD005048.pub4. Review

    Article  Google Scholar 

  16. Gaspar LE, Nag S, Herskovic A, Mantravadi R, Speiser B (1997) American Brachytherapy Society (ABS) consensus guidelines for brachytherapy of esophageal caancer. Clinical Research Committee, American Brachytherapy Society, Philadelphia, PA. Int J Radiat Oncol Biol Phys 38:127–132

    Article  CAS  PubMed  Google Scholar 

  17. Xu D, Li G, Li H, Jia F (2017) Comparison of IMRT versus 3D-CRT in the treatment of esophagus cancer: a systematic review and meta-analysis. Medicine (Baltimore) 96:e7685. https://doi.org/10.1097/MD.0000000000007685

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Wendy W. L. Chan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Science+Business Media, LLC, part of Springer Nature

About this protocol

Check for updates. Verify currency and authenticity via CrossMark

Cite this protocol

Chan, W.W.L., Lam, K.O., Kwong, D.L.W. (2020). Radiotherapy for Thoracic Esophageal Squamous Cell Carcinoma. In: Lam, A. (eds) Esophageal Squamous Cell Carcinoma. Methods in Molecular Biology, vol 2129. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0377-2_23

Download citation

  • DOI: https://doi.org/10.1007/978-1-0716-0377-2_23

  • Published:

  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0376-5

  • Online ISBN: 978-1-0716-0377-2

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics