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Radiotherapy for Cervical Esophageal Squamous Cell Carcinoma

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Esophageal Squamous Cell Carcinoma

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2129))

Abstract

Cervical esophageal carcinoma (CEC) is rare, accounting for 2–10% of esophageal cancers and is mostly squamous cell carcinoma. Because of the anatomical proximity of CEC to larynx, surgical treatment would involve pharyngo-laryngo-esophagectomy (PLE) with inherent high mortality and morbidity. Laryngeal preservation is an important consideration, and definitive chemoradiotherapy is the recommended treatment. Treatment strategy of CEC can be more akin to treatment for head and neck cancers than to thoracic esophageal cancers. Since the exact location, extent of primary and nodal metastasis varies between patients, radiotherapy treatment needs to be individualized. The optimal radiation dose for CEC is uncertain, but retrospective data suggests that higher radiation dose of at least 60 Gy is associated with better local control and survival. Advanced radiotherapy technique, like intensity modulated radiotherapy, is usually required to achieve high dose to tumor while protecting normal tissues from excessive radiation.

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Authors and Affiliations

  1. Department of Clinical Oncology, LKS Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

    Dora L. W. Kwong, Wendy W. L. Chan & Ka On Lam

Authors
  1. Dora L. W. Kwong
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  2. Wendy W. L. Chan
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  3. Ka On Lam
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Corresponding author

Correspondence to Dora L. W. Kwong .

Editor information

Editors and Affiliations

  1. Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, QLD, Australia

    Alfred K. Lam

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Kwong, D.L.W., Chan, W.W.L., Lam, K.O. (2020). Radiotherapy for Cervical Esophageal Squamous Cell Carcinoma. In: Lam, A. (eds) Esophageal Squamous Cell Carcinoma. Methods in Molecular Biology, vol 2129. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0377-2_22

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  • DOI: https://doi.org/10.1007/978-1-0716-0377-2_22

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0376-5

  • Online ISBN: 978-1-0716-0377-2

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