Abstract
It is well known that the retina can be stimulated in vitro and in vivo with monopolar transretinal or local bipolar applied electric current.1-4 These results indi- cate that it might be possible to develop a retina implant that electrically stimulates the remaining cells of the retinal network electrically, even if the photoreceptors are completely degenerated. Current research focuses on two different approaches for the development of an intraocular prosthesis for patients suffering from photoreceptor degeneration. Several groups favour direct electrical stimulation of retinal ganglion cell5-7 from the epiretinal side while Tassiker and Chow proposed in patents to stim- ulate neurons of the inner nuclear layer8-10 from the subretinal side (see also Zrenner et al. in this volume).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
S. Barnes and F. Werblin, 1987, Direct excitatory and lateral inhibitory synaptic inputs to amacrine cells in the tiger salamander retina, Brain Res., 406:233–237.
W.W. Dawson and N.D. Radtke, 1977, The electrical stimulation of the retina by indwelling electrodes. Invest. Ophthalmol. Vis. Sci, 16:249–252.
R.W. Knighton, 1975, An electrically evoked slow potential of the frog’s retina. I. Properties of response, J. Neurophysiol, 38:185–197.
M. Humayun, R. Probst, E. de Juan, K. McCormick, and D. Hickingbotham, 1994, Bipolar surface electrical stimulation of the vertebrate retina, Arch. Ophthalmol, 112:110–116.
R. Eckmiller, 1997, Learning retina implants with epiretinal contacts, Ophthalmic Res., 29:269–280.
M.S. Humayun, E. de Juan Jr., G. Dagnelie, R.J. Greenberg, R.H. Propst, D.H. Phillips, 1996, Visual perception elicited by electrical stimulation of retina in blind humans, Arch. Ophthalmol. 114:40–46.
J. Wyatt and J. Rizzo, 1996, Ocular implants for the blind, IEEE Spectrum, 33:47–53.
A.Y. Chow, 1993, Electrical stimulation of the rabbit retina with subretinal electrodes and high density microphotodiode array implants, Invest. Ophthalmol. Vis. Sci., 34:835 (Abstract).
A.Y. Chow and V.Y. Chow, 1997, Subretinal electrical stimulation of the rabbit retina, Neurosci. Lett., 225:13–16.
E. Zrenner, K.D. Miliczek, V.P. Gabel, H.G. Graf, E. Guenther, H. Haemmerle, B. Hoefflinger, K. Kohler, W. Nisch, M. Schubert, A. Stett, and S. Weiss, 1997, The development of subretinal microphotodiodes for replacement of degenerated photoreceptors, Ophthalmic Res., 29:269–280.
D.R. Crapper and W.K. Noell, 1963, Retinal excitation and inhibition from direct electrical stimulation, J. Neurophysiol., 26:924–947.
A. Kaneko and T. Saito, 1983, Ionic mechanisms underlying the responses of off-center bipolar cells in the carp retina, J. Gen. Physiol., 81:603–612.
J.-I. Toyoda and M. Fujimoto, 1984, Application of transretinal current stimulation for the study of bipolar-amacrine transmission, J. Gen. Physiol., 84:915–925.
W. Nisch, J. Böck, H. Haemmerle, and A. Mohr, 1994, A thin film microelectrode array for monitoring extracellular neuronal activity in vitro, Biosensors & Bioelectronics, 9:737–741.
R.P. Gallemore, E.R. Griff, and R.H. Steinberg, 1988, Evidence in support of a photoreceptoral origin for the “light-peak substance”, Invest. Ophthalmol. Vis. Sci., 29:566–571.
V. Porciatti, P. Bagnoli, and R. Alesci, 1987, On and off activity in the retinal and tectal responses to focal stimulation with uniform or patterned stimulation, Clin. Vision Sci., 2:93–102.
P.A. Sieving, K. Murayama, and F. Naarendorp, 1994, Push-pull model of the primate photopic electroretinogram: A role for hyperpolarizing neurons in shaping the b-wave, Vis. Neurosci., 11:519–532.
R.W. Knighton, 1975, An electrically evoked slow potential of the frog’s retina. II. Identification with PII component of electroretinogram, J. Neurophysiol., 38:198–209.
P.D. Lukasiewicz and F.S. Werblin, 1990, The spatial distribution of excitatory and inhibitory inputs to ganglion cell dendrites int the tiger salamander retina, J. Neurosci., 10:210–221.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Kluwer Academic / Plenum Publishers
About this chapter
Cite this chapter
Weiss, S., Herrmann, T., Stett, A., Zrenner, E., Haemmerle, H. (1999). Analysis of Field Potentials and Spike Patterns Evoked by Local Electrical Stimulation of the Chicken Retina. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degenerative Diseases and Experimental Therapy. Springer, Boston, MA. https://doi.org/10.1007/978-0-585-33172-0_38
Download citation
DOI: https://doi.org/10.1007/978-0-585-33172-0_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-306-46193-4
Online ISBN: 978-0-585-33172-0
eBook Packages: Springer Book Archive