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Genome Wide Approaches in Natural Product Research

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Plant-derived Natural Products

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Summary

Within the last decade, the strategy for pathway discovery in plant secondary metabolism has reversed from a metabolite to protein to gene approach to a gene to pathway strategy. Different genome-wide “omics” strategies apply to gene discovery in model plants with sequenced genomes and plants of pharmaceutical or industrial interest. In this chapter, we provide a brief description as well as a few examples of the main approaches that have so far been applied to plant metabolism. Combination of such global approaches leads to the new field of ‘integrative biology’, which highlights metabolic networks connecting the different branches of primary and “secondary” metabolism.

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  1. Department of Plant Metabolic Responses, Institute for Plant Molecular Biology (IBMP), C.N.R.S., 28 rue Goethe, 67000, Strasbourg, France

    Jürgen Ehlting, Jean-François Ginglinger & Danièle Werck-Reichhart

  2. Centre for Forest Biology, University of Victoria, P.O. Box 3020, STN CSC, Victoria, BC, V8W 3N5, Canada

    Jürgen Ehlting

  3. Michael Smith Laboratories, University of British Columbia, 2185, East Mall, Vancouver, BC, V6T 1Z4, Canada

    Björn Hamberger

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    Ehlting, J., Hamberger, B., Ginglinger, JF., Werck-Reichhart, D. (2009). Genome Wide Approaches in Natural Product Research. In: Osbourn, A., Lanzotti, V. (eds) Plant-derived Natural Products. Springer, New York, NY. https://doi.org/10.1007/978-0-387-85498-4_21

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