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Cancer and Joint Pain

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Encyclopedia of Medical Immunology

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Definition

Musculoskeletal disorders associated with malignancy may be classified as due to (A) direct tumor involvement of bones, joints, and muscles; (B) paraneoplastic syndromes; (C) altered immune surveillance; and (D) adverse reactions to anticancer therapy. Paraneoplastic rheumatic disorders are those cancer-associated rheumatic syndromes that occur at a distance from the primary tumor or metastases, and induced by the malignancy through hormones, peptides, autocrine and paracrine mediators, antibodies, and cytotoxic lymphocytes. Paraneoplastic rheumatic disorders may precede the diagnosis of the underlying tumor, occur at the same time as the tumor becomes manifest, or arise when metastases develop. In contrast to paraneoplastic syndromes, malignant transformation in the course of certain rheumatic disorders is the result of immune dysregulation; the time interval between the onset of the rheumatic disorder and diagnosis of the secondary malignancy may be as long as 20 years...

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Authors and Affiliations

  1. Faculty of Medicine, the Technion-Israel Institute of Technology, Haifa, Israel, The Flieman Hospital, Ramot Remez, Zalman Shneur street, 2263, Haifa, 31021, Israel

    Jochanan E. Naschitz

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  1. Jochanan E. Naschitz
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Correspondence to Jochanan E. Naschitz .

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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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© 2014 Springer Science+Business Media New York

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Naschitz, J.E. (2014). Cancer and Joint Pain. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_8

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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