Synonyms
CD27+ IgM+ IgD+ B cells; IgM memory B cells
Definition
Marginal zone (MZ) B cells are a subpopulation of B lymphocytes that localize at the border of the red and white pulp in the spleen where they are positioned to sample blood-borne antigens. Accordingly, MZ B cells mount rapid and T cell–independent antibody responses to blood-borne pathogens that display repetitive epitopes such as the polysaccharides found on encapsulated bacteria and viral coat proteins. They are derived as a separate lineage from naïve follicular B cells and express a unique phenotype. The antibodies produced by MZ B cells bear little-to-no mutation but often display polyreactive and auto-reactive specificities.
Introduction
Antibodies are a critical component of adaptive immunity and their production is a cooperative effort between different B cell subpopulations (Swanson et al. 2013). MZ B cells contribute to humoral immunity upon pathogen infection by rapidly producing pathogen-specific antibodies...
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Torres, R.M., Pujanauski, L. (2014). Marginal Zone B Cells. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_560
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